Platelet alpha-granule

Platelet alpha-granule

In platelets, the term "alpha granules" is used to describe granules containing several growth factors (such as insulin-like growth factor 1, platelet-derived growth factor, TGFβ), platelet factor 4 which is a heparin-binding chemokine,) and other clotting proteins (such as thrombospondin and fibronectin and von Willebrand factor). The alpha granules express the adhesion molecule P-selectin. The other type of granules within platelets are called dense granules. A deficiency of alpha granules is known as grey platelet syndrome.

ee also

* Dense granule

External links


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • Platelet factor 4 — (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C X C motif) ligand 4 (CXCL4) . This chemokine is released from alpha granules of activated platelets during platelet aggregation, and promotes blood …   Wikipedia

  • Dense granule — Latin granulum delta Code TH H2. Dense granules (also known as dense bodies or delta granules) are specialized secretory organelles …   Wikipedia

  • Pseudo gray platelet syndrome — was described by Cockbill, Burmester, and Heptinstall (1988) who reported a 25 year old woman with a history of mild bruising and bleeding. Bleeding time, activated partial thromboplastin time, prothrombin time, and euglobulin lysis time were… …   Wikipedia

  • Gray platelet syndrome — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 29160 ICD10 = ICD10|D|69|1|d|65 ICD9 = ICDO = OMIM = 139090 MedlinePlus = 000582 eMedicineSubj = eMedicineTopic = MeshID = Gray platelet syndrome, or platelet alpha granule… …   Wikipedia

  • Platelet — Platelets, or thrombocytes, are small cytoplasmic bodies derived from cells. They circulate in the blood of mammals and are involved in hemostasis leading to the formation of blood clots. Like red blood cells, platelets have no nucleus. If the… …   Wikipedia

  • granule — 1. A grainlike particle; a granulation; a minute discrete mass. 2. A very small pill, usually gelatin or sugar coated, containing a drug to be given in a small dose. 3. A colony of the bacterium or …   Medical dictionary

  • alpha granules — 1. the predominant type of granule found in platelets; they are round to oval in shape and contain fibrinogen, platelet factor 4, and various other proteins. 2. large granules in the alpha cells of the islets of Langerhans, which are insoluble in …   Medical dictionary

  • PDGFA — Platelet derived growth factor alpha polypeptide Identifiers Symbols PDGFA; PDGF A; PDGF1 External IDs …   Wikipedia

  • PDGFB — Platelet derived growth factor beta polypeptide PDB rendering based on 1pdg …   Wikipedia

  • CD31 — Platelet/endothelial cell adhesion molecule Identifiers Symbols PECAM1; CD31; FLJ34100; FLJ58394; PECAM 1 External IDs …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”