- Xq28
Xq28 is a
genetic marker on theX chromosome found byDean Hamer and others in 1993. Hamer's study found a link between the Xq28 marker and malehomosexuality , [Hamer, Hu, Magnuson, Hu and Pattatucci (1993) [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8332896 A linkage between DNA markers on the X chromosome and male sexual orientation] . Science 261(5119): pp. 321-7. Retrieved 2007-01-18.] but the original study's results have been disputed. [ [http://news.bbc.co.uk/1/hi/sci/tech/325979.stm Doubt cast on 'gay gene'] ,April 23 ,1999 ,BBC News ]1993 study
The 1993 study by Hamer examined 114 families of gay men and found supposed increased rates of homosexuality among maternal uncles and cousins, but not among paternal relatives.
Genetic linkage was studied in 40 of the families, in which there were two gay brothers. A correlation to Xq28 and othermicrosatellite markers was found in approximately 64% of the cases.1999 study
A further study of these results in 1999 disputed the results. Studying 52 pairs of gay brothers,
George Rice and others found no statistically significant linkage inallele s andhaplotype s and concluded against an X-linked male homosexuality gene. [Rice, Anderson, Risch and Ebers (1999) [http://www.sciencemag.org/cgi/content/abstract/284/5414/665 Male Homosexuality: Absence of Linkage to Microsatellite Markers at Xq28] . Science 23(5414): pp. 665-667. Retrieved 2007-01-18.]When the refuting study was published in "Science", Hamer disputed it, standing by his original results. [ [http://www.sciencemag.org/cgi/content/summary/284/5414/571 Discovery of 'Gay Gene' Questioned] , Ingrid Wickelgren,
April 23 ,1999 .]ee also
*
Biology and sexual orientation References
Wikimedia Foundation. 2010.
