RPL10

Ribosomal protein L10, also known as RPL10, is a human gene.cite web | title = Entrez Gene: RPL10 ribosomal protein L10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6134| accessdate = ]

PBB_Summary
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summary_text = Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.cite web | title = Entrez Gene: RPL10 ribosomal protein L10| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6134| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins. |journal=Biochem. Cell Biol. |volume=73 |issue= 11-12 |pages= 933–47 |year= 1996 |pmid= 8722009 |doi=
*cite journal | author=van den Ouweland AM, Kioschis P, Verdijk M, "et al." |title=Identification and characterization of a new gene in the human Xq28 region. |journal=Hum. Mol. Genet. |volume=1 |issue= 4 |pages= 269–73 |year= 1993 |pmid= 1303197 |doi=
*cite journal | author=van den Ouweland AM, Verdijk M, Mannens MM, van Oost BA |title=The QM gene is X-linked and therefore not involved in suppression of tumorigenesis in Wilms' tumor. |journal=Hum. Genet. |volume=90 |issue= 1-2 |pages= 144–6 |year= 1992 |pmid= 1330878 |doi=
*cite journal | author=Kaneko K, Kobayashi H, Onodera O, "et al." |title=Genomic organization of a cDNA (QM) demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells and its localization to Xq28. |journal=Hum. Mol. Genet. |volume=1 |issue= 7 |pages= 529–33 |year= 1993 |pmid= 1339145 |doi=
*cite journal | author=Bignon C, Roux-Dosseto M, Zeigler ME, "et al." |title=cDNA cloning and genomic analysis of a new multigene family sharing common phylogenetic and expression profiles with the laminin receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 3 |pages= 1165–72 |year= 1992 |pmid= 1534224 |doi=
*cite journal | author=Dowdy SF, Lai KM, Weissman BE, "et al." |title=The isolation and characterization of a novel cDNA demonstrating an altered mRNA level in nontumorigenic Wilms' microcell hybrid cells. |journal=Nucleic Acids Res. |volume=19 |issue= 20 |pages= 5763–9 |year= 1991 |pmid= 1658743 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Matoba R, Okubo K, Hori N, "et al." |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Farmer AA, Johnsen JI, Loftus TM, "et al." |title=Isolation and characterization of the QM promoter. |journal=Nucleic Acids Res. |volume=24 |issue= 11 |pages= 2158–65 |year= 1996 |pmid= 8668549 |doi=
*cite journal | author=Chen EY, Zollo M, Mazzarella R, "et al." |title=Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 659–68 |year= 1997 |pmid= 8733135 |doi=
*cite journal | author=Chan YL, Diaz JJ, Denoroy L, "et al." |title=The primary structure of rat ribosomal protein L10: relationship to a Jun-binding protein and to a putative Wilms' tumor suppressor. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 3 |pages= 952–6 |year= 1996 |pmid= 8780716 |doi= 10.1006/bbrc.1996.1277
*cite journal | author=Inada H, Mukai J, Matsushima S, Tanaka T |title=QM is a novel zinc-binding transcription regulatory protein: its binding to c-Jun is regulated by zinc ions and phosphorylation by protein kinase C. |journal=Biochem. Biophys. Res. Commun. |volume=230 |issue= 2 |pages= 331–4 |year= 1997 |pmid= 9016777 |doi= 10.1006/bbrc.1996.5955
*cite journal | author=Loftus TM, Nguyen YH, Stanbridge EJ |title=The QM protein associates with ribosomes in the rough endoplasmic reticulum. |journal=Biochemistry |volume=36 |issue= 27 |pages= 8224–30 |year= 1997 |pmid= 9204867 |doi= 10.1021/bi970288d
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nguyen YH, Mills AA, Stanbridge EJ |title=Assembly of the QM protein onto the 60S ribosomal subunit occurs in the cytoplasm. |journal=J. Cell. Biochem. |volume=68 |issue= 2 |pages= 281–5 |year= 1998 |pmid= 9443083 |doi=
*cite journal | author=Kenmochi N, Kawaguchi T, Rozen S, "et al." |title=A map of 75 human ribosomal protein genes. |journal=Genome Res. |volume=8 |issue= 5 |pages= 509–23 |year= 1998 |pmid= 9582194 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058

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