RPS27A

Ribosomal protein S27a, also known as RPS27A, is a human gene.cite web | title = Entrez Gene: RPS27A ribosomal protein S27a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6233| accessdate = ]

PBB_Summary
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summary_text = Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi.cite web | title = Entrez Gene: RPS27A ribosomal protein S27a| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6233| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
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*cite journal | author=Adams SM, Sharp MG, Walker RA, "et al." |title=Differential expression of translation-associated genes in benign and malignant human breast tumours. |journal=Br. J. Cancer |volume=65 |issue= 1 |pages= 65–71 |year= 1992 |pmid= 1370760 |doi=
*cite journal | author=Pancré V, Pierce RJ, Fournier F, "et al." |title=Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL). |journal=Eur. J. Immunol. |volume=21 |issue= 11 |pages= 2735–41 |year= 1991 |pmid= 1657614 |doi=
*cite journal | author=Kanayama H, Tanaka K, Aki M, "et al." |title=Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells. |journal=Cancer Res. |volume=51 |issue= 24 |pages= 6677–85 |year= 1992 |pmid= 1660345 |doi=
*cite journal | author=Monia BP, Ecker DJ, Jonnalagadda S, "et al." |title=Gene synthesis, expression, and processing of human ubiquitin carboxyl extension proteins. |journal=J. Biol. Chem. |volume=264 |issue= 7 |pages= 4093–103 |year= 1989 |pmid= 2537304 |doi=
*cite journal | author=Redman KL, Rechsteiner M |title=Identification of the long ubiquitin extension as ribosomal protein S27a. |journal=Nature |volume=338 |issue= 6214 |pages= 438–40 |year= 1989 |pmid= 2538756 |doi= 10.1038/338438a0
*cite journal | author=Lund PK, Moats-Staats BM, Simmons JG, "et al." |title=Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor. |journal=J. Biol. Chem. |volume=260 |issue= 12 |pages= 7609–13 |year= 1985 |pmid= 2581967 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Vladimirov SN, Ivanov AV, Karpova GG, "et al." |title=Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. |journal=Eur. J. Biochem. |volume=239 |issue= 1 |pages= 144–9 |year= 1996 |pmid= 8706699 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kenmochi N, Kawaguchi T, Rozen S, "et al." |title=A map of 75 human ribosomal protein genes. |journal=Genome Res. |volume=8 |issue= 5 |pages= 509–23 |year= 1998 |pmid= 9582194 |doi=
*cite journal | author=Kirschner LS, Stratakis CA |title=Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes. |journal=Biochem. Biophys. Res. Commun. |volume=270 |issue= 3 |pages= 1106–10 |year= 2000 |pmid= 10772958 |doi= 10.1006/bbrc.2000.2568
*cite journal | author=Petersen BO, Wagener C, Marinoni F, "et al." |title=Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1. |journal=Genes Dev. |volume=14 |issue= 18 |pages= 2330–43 |year= 2000 |pmid= 10995389 |doi=
*cite journal | author=Bolton D, Evans PA, Stott K, Broadhurst RW |title=Structure and properties of a dimeric N-terminal fragment of human ubiquitin. |journal=J. Mol. Biol. |volume=314 |issue= 4 |pages= 773–87 |year= 2002 |pmid= 11733996 |doi= 10.1006/jmbi.2001.5181
*cite journal | author=Yoshihama M, Uechi T, Asakawa S, "et al." |title=The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. |journal=Genome Res. |volume=12 |issue= 3 |pages= 379–90 |year= 2002 |pmid= 11875025 |doi= 10.1101/gr.214202
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cohen BD, Bariteau JT, Magenis LM, Dias JA |title=Regulation of follitropin receptor cell surface residency by the ubiquitin-proteasome pathway. |journal=Endocrinology |volume=144 |issue= 10 |pages= 4393–402 |year= 2003 |pmid= 12960054 |doi= 10.1210/en.2002-0063
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Li H, Seth A |title=An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein. |journal=Oncogene |volume=23 |issue= 10 |pages= 1801–8 |year= 2004 |pmid= 14755250 |doi= 10.1038/sj.onc.1207319

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