Calcitonin gene-related peptide
- Calcitonin gene-related peptide
protein
Name = calcitonin-related polypeptide, beta
caption =
width =
HGNCid = 1438
Symbol = CALCB
AltSymbols = CALC2
EntrezGene = 797
OMIM = 114160
RefSeq = NM_000728
UniProt = P10092
PDB =
ECnumber =
Chromosome = 11
Arm = p
Band = 14.2
LocusSupplementaryData = -p12
Calcitonin gene related peptide (CGRP) is derived, with calcitonin, from the CT/CGRP gene located on chromosome 11. CGRP is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known.
CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonised by capsazepine. [cite journal |title=Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. |author=Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sørgård M, Di Marzo V, Julius D, Högestätt ED |journal=Nature |date=1999-07-29 |volume=400 |issue=6743 |pages=452—457 |pmid=10440374] CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches. Merck has announced promising results in Phase III trials with Telcagepant, a CGRP antagonist. [http://www.merck.com/newsroom/press_releases/research_and_development/2008_0627a.html?src=rss]
External links
*
References
Wikimedia Foundation.
2010.
Look at other dictionaries:
Calcitonin Gene-Related Peptide — Calcitonin related Polypeptid CALCA grün im Präpeptid, theoretische Struktur nach PDB … Deutsch Wikipedia
Calcitonin-Gene-Related-Peptide-Rezeptor — Masse/Länge Primärstruktur 439 Aminosäuren … Deutsch Wikipedia
Calcitonin-Gene-Related-Peptide-Rezeptorantagonist — Calcitonin Gene Related Peptide Rezeptorantagonisten (kurz CGRP Rezeptorantagonisten oder CGRP Antagonisten) sind Arzneistoffe, welche die Wirkung des Calcitonin Gene Related Peptide (CGRP) durch Blockade seines Rezeptors, dem Calcitonin Gene… … Deutsch Wikipedia
calcitonin gene related peptide — (= CGRP) Neuropeptide of 37 amino acids with structural homology to salmon calcitonin. Co localizes with substance P in neurons. Intracerebral administration of CGRP leads to a rise in noradrenergic sympathetic outflow, a rise in blood pressure,… … Dictionary of molecular biology
calcitonin gene–related peptide — a 37–amino acid polypeptide encoded by the calcitonin gene, widely distributed in the central and peripheral nervous systems and also occurring in the adrenal medulla and gastrointestinal tract; it is a potent vasodilator and a neurotransmitter … Medical dictionary
Calcitonin — is a 32 amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C cells) of the thyroid, and in many other animals in the ultimobranchial body.[1] It acts to reduce blood calcium… … Wikipedia
Calcitonin — vom Lachs nach PDB … Deutsch Wikipedia
Peptide relié au gène calcitonine — Le peptide relié au gène calcitonine (PRGC) (ou calcitonin gene related peptide CGRP) est un des médiateurs de la douleur tout comme la substance P. Le premier relais de la transmission des informations nociceptives se trouve dans la corne… … Wikipédia en Français
peptide — A compound of two or more amino acid s in which a carboxyl group of one is united with an amino group of another, with the elimination of a molecule of water, thus forming a p. bond, –CO–NH–; i.e., a substituted amide. Cf.:eupeptide bond … Medical dictionary
Pituitary adenylate cyclase-activating peptide — Adenylate cyclase activating polypeptide 1 (pituitary) PDB rendering based on 2d2p … Wikipedia
