Drug intolerance

Drug intolerance or drug sensitivity is a lower threshold to the normal pharmacologic action of a drug. It is not to be confused with drug allergy. Drug intolerance is uncommon and idiopathic, thus extremely difficult to predict except in persons with a prior history or a family history of intolerance to that specific drug. Some drug intolerances are known to result from genetic variants of drug metabolism.

Examples

• Tinnitus after a normal dose of aspirin
• Liver failure (possibly also kidney failure) after a normal dose of acetaminophen
• Fatal poisoning in a breastfed newborn baby due to normal use of codeine by the mother^[1]

Analgesic intolerance

Intolerance to analgesics, particularly NSAIDs, is relatively common. Its cause is believed to be variation in the metabolism of arachidonic acid. Symptoms include chronic rhinosinusitis with nasal polyps, asthma, gastrointestinal ulcers, angioedema, and urticaria.^[2]

See also

• Contraindication
• Food intolerance

References

1. ^ Madadi P, Koren G, Cairns J, et al. (January 2007). "Safety of codeine during breastfeeding: fatal morphine poisoning in the breastfed neonate of a mother prescribed codeine". Can Fam Physician 53 (1): 33–5. PMC 1952551. PMID 17872605. http://www.cfp.ca/cgi/pmidlookup?view=long&pmid=17872605. 
2. ^ Förster U, Olze H (April 2008). "[Analgesic intolerance (AI). Key position of ENT physicians for early detection of this condition]" (in German). HNO 56 (4): 443–50; quiz 451. doi:10.1007/s00106-008-1701-6. PMID 18389300. 

This health-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Pharmacodynamics Health stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат High bit rate Digital Subscriber Line Unaccompanied Sonata and Other Stories Look at other dictionaries: drug intolerance — 1. inability to continue taking, or difficulty in continuing to take, a medication because of an adverse side effect that is not immunity mediated. 2. the state of reacting to the normal pharmacologic doses of a drug with the symptoms of… …   Medical dictionary Drug allergy — Classification and external resources ICD 10 T88.7 ICD 9 995.27 A drug allergy is an allergy to a drug, most commonly a medication. Medical attention …   Wikipedia Intolerance — is an antonym to tolerance . The term may refer to one of the following.;Medical/biological conditionsIn medical/biological context the term is commonly used synonymously with sensitivity , e.g., salycylate sensitivity , cold sensitivity ,… …   Wikipedia drug — drug1 /drug/, n., v., drugged, drugging. n. 1. Pharm. a chemical substance used in the treatment, cure, prevention, or diagnosis of disease or used to otherwise enhance physical or mental well being. 2. (in federal law) a. any substance… …   Universalium Drug — /droog/, n. Zoroastrianism. the cosmic principle of disorder and falsehood. Cf. Asha. [ < Avestan drauga] * * * I Any chemical agent that affects the function of living things. Some, including antibiotics, stimulants, tranquilizers,… …   Universalium Drug liberalization — is the process of eliminating or reducing drug prohibition laws. Variations of drug liberalization (also spelled liberalisation) include drug relegalization, drug legalization, and drug decriminalization [1] Contents 1 Policies 1.1 Drug re… …   Wikipedia intolerance — Abnormal metabolism, excretion, or other disposition of a given substance; term often used to indicate impaired utilization or disposal of dietary constituents. hereditary fructose i. [MIM*229600] a metabolic error due to deficiency …   Medical dictionary intolerance — /ɪnˈtɒlərəns/ (say in toluhruhns) noun 1. lack of toleration; indisposition to tolerate contrary opinions or beliefs. 2. incapacity or indisposition to bear or endure: intolerance of heat. 3. an intolerant act. 4. an abnormal sensitivity or… …   intolerance — /in tol euhr euhns/, n. 1. lack of toleration; unwillingness or refusal to tolerate or respect contrary opinions or beliefs, persons of different races or backgrounds, etc. 2. incapacity or indisposition to bear or endure: intolerance to heat. 3 …   Universalium intolerance — noun Date: 1765 1. the quality or state of being intolerant 2. exceptional sensitivity (as to a drug); specifically inability to properly metabolize or absorb a substance …   New Collegiate Dictionary 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”