GITR

GITR

GITR (glucocorticoid-induced tumor necrosis factor receptor) is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.cite web
last = Jun Shimizu, Ph.D | first = | authorlink = | coauthors = | title = Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance | work = | publisher = Tokyo Metropolitan Institute of Gerontology | date = 2002 | url = http://www.tmig.or.jp/topics/topics_01.html | format = Web | doi = | accessdate = 2007-11-17 ] In mouse models, GITR was initially noted to be selectively enriched on the surface of regulatory T cells, making this an attractive potential surface marker for these rare cells. However, subsequent studies revealed GITR to also be up-regulated on any activated T cells in humans, thus undermining its utility as a regulatory T cell marker.

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