TNFSF18

TNFSF18

Tumor necrosis factor (ligand) superfamily, member 18, also known as TNFSF18, is a human gene.cite web | title = Entrez Gene: TNFSF18 tumor necrosis factor (ligand) superfamily, member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8995| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.cite web | title = Entrez Gene: TNFSF18 tumor necrosis factor (ligand) superfamily, member 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8995| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kwon B, Yu KY, Ni J, "et al." |title=Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. |journal=J. Biol. Chem. |volume=274 |issue= 10 |pages= 6056–61 |year= 1999 |pmid= 10037686 |doi=
*cite journal | author=Gurney AL, Marsters SA, Huang RM, "et al." |title=Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. |journal=Curr. Biol. |volume=9 |issue= 4 |pages= 215–8 |year= 1999 |pmid= 10074428 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Yu KY, Kim HS, Song SY, "et al." |title=Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 2 |pages= 433–8 |year= 2003 |pmid= 14521928 |doi=
*cite journal | author=Kim BJ, Li Z, Fariss RN, "et al." |title=Constitutive and cytokine-induced GITR ligand expression on human retinal pigment epithelium and photoreceptors. |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 9 |pages= 3170–6 |year= 2004 |pmid= 15326137 |doi= 10.1167/iovs.03-0919
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Nardelli B, Zaritskaya L, McAuliffe W, "et al." |title=Osteostat/tumor necrosis factor superfamily 18 inhibits osteoclastogenesis and is selectively expressed by vascular endothelial cells. |journal=Endocrinology |volume=147 |issue= 1 |pages= 70–8 |year= 2006 |pmid= 16179414 |doi= 10.1210/en.2005-0518
*cite journal | author=Hanabuchi S, Watanabe N, Wang YH, "et al." |title=Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). |journal=Blood |volume=107 |issue= 9 |pages= 3617–23 |year= 2006 |pmid= 16397134 |doi= 10.1182/blood-2005-08-3419
*cite journal | author=Mahesh SP, Li Z, Liu B, "et al." |title=Expression of GITR ligand abrogates immunosuppressive function of ocular tissue and differentially modulates inflammatory cytokines and chemokines. |journal=Eur. J. Immunol. |volume=36 |issue= 8 |pages= 2128–38 |year= 2006 |pmid= 16874737 |doi= 10.1002/eji.200635893
*cite journal | author=Baumgartner-Nielsen J, Vestergaard C, Thestrup-Pedersen K, "et al." |title=Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis. |journal=Acta Derm. Venereol. |volume=86 |issue= 5 |pages= 393–8 |year= 2006 |pmid= 16955181 |doi= 10.2340/00015555-0118
*cite journal | author=Baltz KM, Krusch M, Bringmann A, "et al." |title=Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. |journal=FASEB J. |volume=21 |issue= 10 |pages= 2442–54 |year= 2007 |pmid= 17360848 |doi= 10.1096/fj.06-7724com
*cite journal | author=Tuyaerts S, Van Meirvenne S, Bonehill A, "et al." |title=Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells. |journal=J. Leukoc. Biol. |volume=82 |issue= 1 |pages= 93–105 |year= 2007 |pmid= 17449724 |doi= 10.1189/jlb.0906568
*cite journal | author=Bae EM, Kim WJ, Suk K, "et al." |title=Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages. |journal=Mol. Immunol. |volume=45 |issue= 2 |pages= 523–33 |year= 2007 |pmid= 17602748 |doi= 10.1016/j.molimm.2007.05.013
*cite journal | author=Kim YS, Jung HW, Choi J, "et al." |title=Expression of AITR and AITR ligand in breast cancer patients. |journal=Oncol. Rep. |volume=18 |issue= 5 |pages= 1189–94 |year= 2007 |pmid= 17914571 |doi=

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  • Tumor necrosis factors — TNF(Tumour Necrosis Factor) family [[Image: Model of TNF alpha, produced by M. musculus, based on PDB structure 2TNF (1.4Å Resolution). Different colors represent different monomers. Baeyens, KJ et al. (1999) …   Wikipedia

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