Wormbase

WormBase is an online bioinformatics database of the biology and genome of the model organism "Caenorhabditis elegans" and related nematodes. It is used by the "C. elegans" research community both as an information resource and as a mode to publish and distribute their results. The database is constantly updated and new versions are released at regular intervals throughout the year.

Contents

WormBase comprises the following main data sets:

*The annotated genomes of "C. elegans", "C. briggsae", and "C. remanei";
*Hand-curated annotations describing the function of ~20,000 "C. elegans" genes;
*Gene families;
*Comprehensive information on mutant alleles and their phenotypes;
*Whole-genome RNAi ("RNA interference") screens;
*Genetic maps, markers and polymorphisms;
*The "C. elegans" physical map;
*Gene expression profiles (stage, tissue and cell) from microarrays, SAGE analysis and GFP promoter fusions;
*The complete cell lineage of the worm;
*The wiring diagram of the worm nervous system;
*Protein-protein interaction Interactome data;
*Genetic regulatory relationships;
*Details of intra- and inter-specific sequence homologies (with links to other model organism databases).

In addition, WormBase contains an up-to-date searchable bibliography of "C. elegans" research and is linked to the WormBook project.

Tools

WormBase offers many ways of searching and retrieving data from the database:

* WormMart - a tool for retrieving varied information on many genes (or the sequences of those genes).
* Genome Browser - browse the genes of "C. elegans" (and other species) in their genomic context
* TextPresso - a search tool that queries published "C. elegans" literature (including meeting abstracts)

WormBase Management

WormBase is a collaboration among the Wellcome Trust Sanger Institute, Cold Spring Harbor Laboratory, Washington University at St. Louis, and the California Institute of Technology. It is supported by grants from the National Institutes of Health and the British Medical Research Council.

External links

* [http://www.wormbase.org/ WormBase]
* [http://www.wormbook.org/ The WormBook website] , the online textbook companion to WormBase.
* [http://www.textpresso.org/ Textpresso] , search engine for C. elegans and other biological literature.
* [http://www.wormbase.org/wiki/index.php/Main_Page WormBase Wiki]
* [http://www.sanger.ac.uk/Projects/C_elegans/WORMBASE/current/release_notes.txt Release notes] , details of the latest WormBase release
* [http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16381915 WormBase: better software, richer content] Nucleic Acids Research article describing WormBase (2006).