Coacervate

Coacervate

A coacervate is a tiny spherical droplet of assorted organic molecules (specifically, lipid molecules) which is held together by hydrophobic forces from a surrounding liquid.

Coacervates were famously proposed by Alexander Oparin as crucial in his early theory of abiogenesis (origin of life). This theory proposes that metabolism predated information replication. The debate as to whether metabolism or molecules capable of Template replication came first in the origins of life remains open[1] and for decades Oparin's theory was the leading approach to the origin of life question.

Coacervates measure 1 to 100 micrometers across, possess osmotic properties and form spontaneously from certain dilute organic solutions. Their name derives from the Latin coacervare, meaning "to assemble together or cluster". Though they were once suggested to have played a significant role in the evolution of cells and, therefore, of life itself, and are part of many modern theories of abiogenesis.

Contents

Formation

In water, organic chemicals do not necessarily remain uniformly dispersed but may separate out into layers or droplets. If the droplets which form contain a colloid, rich in organic compounds and are surrounded by a tight skin of water molecules, then they are known as coacervates. These structures were first investigated by the Dutch chemist H.G. Bungenberg de Jong, in 1932. A wide variety of solutions can give rise to them; for example, coacervates form spontaneously when a protein, such as gelatin, reacts with gum arabic. They are interesting not only in that they provide a locally segregated environment but also in that their boundaries allow the selective absorption of simple organic molecules from the surrounding medium. In Oparin's view this amounts to an elementary form of metabolism. Bernal commented that they are "the nearest we can come to cells without introducing any biological – or, at any rate, any living biological – substance." However, the lack of any mechanism by which coacervates can reproduce leaves them far short of being living systems.[2]

Complex coacervation

Complex coacervation refers to the phase separation of a liquid precipitate, or phase, when solutions of two hydrophilic colloids are mixed under suitable conditions. The general outline of the processes consists of three steps carried under continuous agitation [3]:

Step 1: Formation of three immiscible chemical phases

The immiscible chemical phases are (i) a liquid manufacturing vehicle phase (ii) a core material phase and (iii) a coating material phase. To form the three phases, the core material is dispersed in a solution of the coating polymer, the solvent for the polymer being the liquid manufacturing vehicle phase. The coating material phase, an immiscible polymer in a liquid state, is formed by utilizing one of the methods of phase separation coacervation, that is,

  • By changing the temperature of the polymer solution
  • By adding a salt
  • By adding a non-solvent
  • By adding incompatible polymer to the polymer solution
  • By inducing a polymer-polymer interaction.

Step 2: Depositing the liquid polymer coating upon the core material

This is accomplished by controlled, physical mixing of the coating material (while liquid) and the core material in the manufacturing vehicle. Deposition of the liquid polymer coating around the core material occurs if the polymer is adsorbed at the interface formed between the core material and the liquid vehicle phase, and this adsorption phenomenon is a prerequisite to effective coating. The continued deposition of the coating material is promoted by a reduction in the total free interfacial energy of the system, brought about by the decrease of the coating material surface area during coalescence of the liquid polymer droplets.

Step 3: Rigidizing the coating

This is usually done by thermal, cross linking or desolvation techniques, to form a self sustaining microcapsule.

See also

References

  1. ^ Origins of Life and Evolution of the Biosphere, Volume 40, Numbers 4-5, October 2010 , pp. 347-497(151)
  2. ^ Dick, Steven J. (1999). The Biological Universe: The Twentieth Century Extraterrestrial Life Debate and the Limits of Science. Cambridge University Press. pp. 340. ISBN 9780521663618. 
  3. ^ Leon Lachman, Herbert A. Lieberman, Joseph L. Kanig, “The Theory and Practice of Industrial Pharmacy”, 3rd edition, pp.420.

External links


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • Coacervate — Co a*cer vate, a. [L. coacervatus, p. p. of coacervare to heap up; co + acervare. See {Acervate}.] Raised into a pile; collected into a crowd; heaped. [R.] Bacon. [1913 Webster] …   The Collaborative International Dictionary of English

  • Coacervate — Co a*cer vate, v. t. To heap up; to pile. [R.] [1913 Webster] …   The Collaborative International Dictionary of English

  • coacervate — coacervate. См. коацерват. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • coacervate — noun Etymology: Latin coacervatus, past participle of coacervare to heap up, from co + acervus heap Date: 1929 an aggregate of colloidal droplets held together by electrostatic attractive forces • coacervate adjective • coacervation …   New Collegiate Dictionary

  • coacervate — n. /koh as euhr vit, vayt , koh euh serr vit/; v. /koh as euhr vayt , koh euh serr vayt/, n., v., coacervated, coacervating. n. 1. Physical Chem. a reversible aggregation of liquid particles in an emulsion. v.t., v.i. 2. to make or become a… …   Universalium

  • coacervate — co•ac•er•vate n. [[t]koʊˈæs ər vɪt, ˌveɪt, ˌkoʊ əˈsɜr vɪt[/t]] v. [[t] ˌveɪt, veɪt[/t]] n. v. 1) chem. a reversible aggregation of liquid particles in an emulsion 2) chem. to make or become a coacervate • Etymology: 1620–30; < L coacervātus,… …   From formal English to slang

  • coacervate — adj. [L. coacervare, to heap up] Piled up; collected into a crowd; densely clustered …   Dictionary of invertebrate zoology

  • coacervate — Colloidal aggregation containing a mixture of organic compounds. One theory of the evolution of life is that the formation of coacervates in the primaeval soup was a step towards the development of cells …   Dictionary of molecular biology

  • coacervate — noun /kəʊˈasəveɪt/ The microsphere droplet that result from coacervation …   Wiktionary

  • coacervate — An aggregate of colloidal particles separated out of an emulsion (coacervation) by the addition of some third component (coacervating agent). [L. coacervare, pp. atus, to collect in a mass] * * * co·ac·er·vate kō as ər .vāt n an aggregate of… …   Medical dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”