Scipio may refer to:
- Scipio, a representation of the Cornelii Scipiones, branch of the illustrious Cornelii family from Ancient Rome.
- Scipio Africanus, Roman general who defeated Hannibal at Zama, the final battle of the Second Punic War.
- Scipio Aemilianus Africanus, leading general and politician of the Roman Republic who led the final siege and destruction of Carthage in 146 BC.
- Scipio Africanus Jones, African-American educator
- Scipio Africanus (slave), African slave in England known for his epitaph
- Scipio Colombo, Italian opera singer
- Scipio Moorhead, African-American artist
- Scipio Slataper, writer from Trieste
- Scipio Spinks, baseball player
- Scipion Abeille, French surgeon
- Scipione Ammirato, Italian historian
- Scipione Barbò Soncino, Italian jurist
- Scipione Borghese, Italian cardinal
- Scipione Borghese (prince), Italian ruler
- Scipione Breislak, Italian geologist
- Scipione del Ferro, Italian mathematician
- Scipione de' Ricci, Italian bishop
- Scipione Gentili, Italian law professor
- Scipione (Gino Bonichi), Italian painter
- Scipione Pulzone, Italian painter
- Scipione Rebiba, Italian cardinal
- Scipione Tecchi, Italian cardinal
- Elmer Scipio Dundy, Nebraska judge
- Andrew Scipione, Australian police commissioner
- Francesco Scipione, marchese di Maffei, Italian writer
In the United States:
- Scipio, Indiana (Jennings County)
- Scipio Township, Allen County, Indiana
- Scipio Township, LaPorte County, Indiana
- Scipio, New York (Cayuga County)
- Scipio Township, Meigs County, Ohio
- Scipio Township, Seneca County, Ohio
- Scipio, Ohio (Butler County)
- Scipio, Utah (Millard County)
- Dream of Scipio, story by Cicero
- The Dream of Scipio (book), book by Iain Pears
- Il sogno di Scipione, dramatic serenade by Mozart
- Il sogno di Scipione, Opera by Judith Weir
- Scipione, opera by Handel
- Scipione affricano, Opera by Francesco Cavalli
- Hannibal and Scipio, play by Thomas Nabbes
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