Tangeritin

Tangeritin

Chembox new
Name = Tangeritin
ImageFile = Tangeritin_structure.png ImageName =
IUPACName = 5,6,7,8-tetramethoxy-2-
(4-methoxyphenyl)-4H-
1-benzopyran-4-one
Section1 = Chembox Identifiers
CASNo = 481-53-8
SMILES = O=C2C1=C(OC)C(OC)=C(OC)C(OC)
=C1OC(C3=CC=C(OC)C=C3)=C2
Section2 = Chembox Properties
Formula = C20H20O7
MolarMass = 372.37 g/mol
MeltingPt = 155-156 °C

Tangeritin is a polymethoxylated flavone that is found in tangerine and other citrus peels. Tangeritin strengthens the cell wall and protects it from invasion Fact|date=January 2008.

Although few randomized, double-blind human studies have been done, animal research shows the potential of tangeritin as a cholesterol lowering agent [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15137829&query_hl=2&itool=pubmed_docsum Hypolipidemic effects and absorption of citrus polymethoxylated flavones in hamsters with diet-induced hypercholesterolemia] ] . A hamster study showed potential protective effects against Parkinson's disease [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11726811&query_hl=2&itool=pubmed_docsum Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease] ] . Tangeritin shows potential as an anti cancer agent. In in vitro studies, tangeritin appears to counteract some of the adaptations of cancer cells. Tangeritin induced apoptosis in leukemia cells while sparing normal cells [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8519648&query_hl=6&itool=pubmed_docsum Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes] ] . It counteracts tumor suppression of gap junction intercellular signaling [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9103293&query_hl=2&itool=pubmed_DocSum Flavonoids (apigenin, tangeretin) counteract tumor... [Cancer Lett. 1997 - PubMed Result ] ] . It acts to freeze cancer cells in phase G1 of the cell cycle, preventing replication. In summary, "in vitro" studies show antimutagenic [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8693033&query_hl=2&itool=pubmed_DocSum Inhibition of bacterial mutagenesis by Citrus flav... [Planta Med. 1996 - PubMed Result ] ] , antiinvasive [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2924447&query_hl=2&itool=pubmed_DocSum The flavonoid tangeretin inhibits invasion of MO4 ... [Clin Exp Metastasis. 1989 May-Jun - PubMed Result ] ] and antiproliferative [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1998943&query_hl=2&itool=pubmed_DocSum Antiproliferative effects of citrus flavonoids on ... [Cancer Lett. 1991 - PubMed Result ] ] effects. One caveat is that tangeritin appears to counteract the anticancer drug tamoxifen and to suppress the activity of natural killer cells [ [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11056327&query_hl=2&itool=pubmed_docsum Inhibition of tamoxifen's therapeutic benefit by t... [Eur J Cancer. 2000 - PubMed Result ] ] .

Tangeritin is commercially available as a dietary supplement.

ee also

*Apigenin
*Luteolin

References


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