- Securin
Protbox topfields|Gene= [http://www.ncbi.nih.gov/entrez/query.fcgi?db=nucleotide&cmd=search&term=U12185&doptcmdl=GenBank] #ID : AAB00106.1
Structure=Unknown|Review= [http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8601617&dopt=Abstract] Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).,
[http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8985178&dopt=Abstract] Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.,
[http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9635435&dopt=Abstract] Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.Securin is a protein involved in anaphase triggering. It has two identified roles; the first one is to help the transport of
separase to the nucleus and the second role is to inhibit the catalytic activity ofseparase . Securin is ubiquitinated by theAnaphase Promoting Complex (APC), and then degraded by theProteasome , releasingseparase .In
yeast securin is known as Pds1p.
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