Securin

Protbox topfields|Gene= [http://www.ncbi.nih.gov/entrez/query.fcgi?db=nucleotide&cmd=search&term=U12185&doptcmdl=GenBank] #ID : AAB00106.1
Structure=Unknown|Review= [http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8601617&dopt=Abstract] Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).,
[http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8985178&dopt=Abstract] Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.,
[http://www.ncbi.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9635435&dopt=Abstract] Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

Securin is a protein involved in anaphase triggering. It has two identified roles; the first one is to help the transport of separase to the nucleus and the second role is to inhibit the catalytic activity of separase. Securin is ubiquitinated by the Anaphase Promoting Complex (APC), and then degraded by the Proteasome, releasing separase.

In yeast securin is known as Pds1p.