Atmospheric pressure chemical ionization

Atmospheric pressure chemical ionization

Infobox chemical analysis
name = Atmospheric pressure chemical ionization

caption =Atmospheric pressure chemical ionization interface
acronym = APCI
classification =Mass spectrometry
analytes = Organic molecules
related = Chemical ionization
hyphenated = Liquid chromatography-mass spectrometry

Atmospheric pressure chemical ionization (APCI) is an ionization method used in mass spectrometry. It is a form of chemical ionization which takes place at atmospheric pressure.cite journal |author=Prakash C, Shaffer CL, Nedderman A |title=Analytical strategies for identifying drug metabolites |journal=Mass spectrometry reviews |volume=26 |issue=3 |pages=340–69 |year=2007 |pmid=17405144 |doi=10.1002/mas.20128]

How it works

APCI allows for the high flow rates typical of standard bore HPLC to be used directly, often without diverting the larger fraction of volume to waste. Typically the mobile phase containing eluting analyte is heated to relatively high temperatures (above 400 degrees Celsius), sprayed with high flow rates of nitrogen and the entire aerosol cloud is subjected to a corona discharge that creates ions. Often APCI can be performed in a modified ESI source. This is basically a gas phase ionisation, unlike ESI which is a liquid phase ionisation process. Also, we can use nonpolar solvent for solution making instead of polar solvent for supporting ions in solution as gaseous state conversion of solvent before reaching to corona discharge pin is carried out here, which well supports the ions formed. Typically, APCI is a less "soft" ionization technique than ESI, i.e. it generates more fragment ions relative to the parent ion.cite journal |author=Zaikin VG, Halket JM |title=Derivatization in mass spectrometry--8. Soft ionization mass spectrometry of small molecules |journal=European journal of mass spectrometry (Chichester, England) |volume=12 |issue=2 |pages=79–115 |year=2006 |pmid=16723751 |doi=10.1255/ejms.798]

ee also



Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Atmospheric Pressure Chemical Ionization — (chemische Ionisation bei Atmosphärendruck, APCI) ist ein Ionisierungsverfahren, das in Massenspektrometern verwendet wird. Es ist eine Form der chemischen Ionisierung bei atmosphärischen Druck. Eine Lösung des Analyten wird durch eine Kapillare… …   Deutsch Wikipedia

  • Chemical ionization — (CI) is an ionization technique used in mass spectrometry.[1][2][3] Chemical ionization is a lower energy process than electron ionization. The lower energy yields less fragmentation, and usually a simpler spectrum. A typical CI spectra has an… …   Wikipedia

  • Contactless Atmospheric Pressure Ionization — (or Contactless API ) is a technique (an ion source) used for analysis of liquid and solid samples by mass spectrometry. Contactless API can be operated without an additional electric power supply (supplying voltage to the source emitter), gas… …   Wikipedia

  • Desorption electrospray ionization — (DESI) Acronym DESI Classification Mass spectrometry Analytes Organic molecules Biomolecules Other techniques Related Electrospray ionization Atmospheric pressure chemical ionization …   Wikipedia

  • Atmospheric electricity — is the regular diurnal variations of the Earth s atmospheric electromagnetic network (or, more broadly, any planet s electrical system in its layer of gases). The Earth’s surface, the ionosphere, and the atmosphere is known as the global… …   Wikipedia

  • Sonic spray ionization — (SSI) is method for creating ions from a liquid solution, for example, a mixture of methanol and water. A pneumatic nebulizer is used to turn the solution into a supersonic spray of small droplets. Ions are formed when the solvent evaporates and… …   Wikipedia

  • Pressure measurement — The construction of a bourdon tube gauge, construction elements are made of brass Many techniques have been developed for the measurement of pressure and vacuum. Instruments used to measure pressure are called pressure gauges or vacuum gauges. A… …   Wikipedia

  • Chemical element — The periodic table of the chemical elements A chemical element is a pure chemical substance consisting of one type of atom distinguished by its atomic number, which is the number of protons in its nucleus.[1] Familiar examples of …   Wikipedia

  • Atmospheric reentry — refers to the movement of human made or natural objects as they enter the atmosphere of a planet from outer space, in the case of Earth from an altitude above the edge of space. This article primarily addresses the process of controlled reentry… …   Wikipedia

  • Penning ionization — is a form of chemi ionization, an ionization process involving reactions between neutral atoms and/or molecules. [Penning, F. M. Die Naturwissenschaften , 1927, 15, 818. Über Ionisation durch metastabile Atome. ] cite journal |author=Arango CA,… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”