Sonic spray ionization

Sonic spray ionization (SSI) is method for creating ions from a liquid solution, for example, a mixture of methanol and water. A pneumatic nebulizer is used to turn the solution into a supersonic spray of small droplets. Ions are formed when the solvent evaporates and the statistically unbalanced charge distribution on the droplets leads to a net charge. Complete desolvation results in ions that can be detected using mass spectrometry.cite journal |author=Hirabayashi A, Sakairi M, Koizumi H |title=Sonic spray mass spectrometry |journal=Anal. Chem. |volume=67 |issue=17 |pages=2878–82 |year=1995 |pmid=8779414 |doi=]

Applications

Sonic spray ionization has been coupled with high performance liquid chromatography for the analysis of drugs.cite journal |author=Arinobu T, Hattori H, Seno H, Ishii A, Suzuki O |title=Comparison of SSI with APCI as an interface of HPLC-mass spectrometry for analysis of a drug and its metabolites |journal=J. Am. Soc. Mass Spectrom. |volume=13 |issue=3 |pages=204–8 |year=2002 |pmid=11908800 |doi=] cite journal |author=Dams R, Benijts T, Günther W, Lambert W, De Leenheer A |title=Sonic spray ionization technology: performance study and application to a LC/MS analysis on a monolithic silica column for heroin impurity profiling |journal=Anal. Chem. |volume=74 |issue=13 |pages=3206–12 |year=2002 |pmid=12141684 |doi=] Oligonucleotides have been studied with this method.cite journal |author=Huang M, Hirabayashi A, Okumura A, Hirabayashi Y |title=Matrix effect on the analysis of oligonucleotides by using a mass spectrometer with a sonic spray ionization source |journal=Anal Sci |volume=17 |issue=10 |pages=1179–82 |year=2001 |pmid=11990592 |doi=] cite journal |author=Huang M, Hirabayashi A |title=Multi-charged oligonucleotide ion formation in sonic spray ionization |journal=Anal Sci |volume=18 |issue=4 |pages=385–90 |year=2002 |pmid=11999509 |doi=] SSI has been used in a manner similar to desorption electrospray ionizationcite journal |author=Haddad R, Sparrapan R, Eberlin MN |title=Desorption sonic spray ionization for (high) voltage-free ambient mass spectrometry |journal=Rapid Commun. Mass Spectrom. |volume=20 |issue=19 |pages=2901–5 |year=2006 |pmid=16941547 |doi=10.1002/rcm.2680] and has been couplet with thin layer chromatography in this manner.cite journal |author=Haddad R, Milagre HM, Catharino RR, Eberlin MN |title=Easy Ambient Sonic-Spray Ionization Mass Spectrometry Combined with Thin-Layer Chromatography |journal=Anal. Chem. |volume= |issue= |pages= |year=2008 |pmid=18331004 |doi=10.1021/ac702216q]

ee also

*Electrospray
*Thermospray
*Atmospheric pressure chemical ionization

References