List of recombinant proteins
- List of recombinant proteins
Since human recombinants have replaced the animal version in human therapeutics, the prefix of "rh" for "human recombinant" appears less and less in the literature
Human recombinants that largely replaced animal or harvested from human types
*Human growth hormone (rhGH) Humatrope from Lilly and Serostim from Serono replaced cadaver harvested human growth hormone
*Human insulin (rhI) Humulin from Lilly and Novolin from Novo Nordisk among others; largely replaced bovine and porcine insulin for human therapy. Some prefer to continue using the animal-sourced preparations, as there is some evidence that synthetic insulin varieties are more likely to induce hypoglycemia unawareness. Remaining manufacturers of highly-purified animal-sourced insulin include the U.K.'s Wockhardt Ltd. (headquartered in India), Poland's Polfa Tarchomin S.A., Argentina's Laboratorios Beta S.A., and China's Wanbang Biopharma Co.
*Follicle-stimulating hormone FSH replaced Serono's Pergonal which was previously isolated from post-menopausal female urine
*Factor VIII Kogenate from Bayer replaced blood harvested factor VIII
Human recombinants with recombination as only source
*Erythropoietin (EPO) Epogen from Amgen
*Granulocyte colony-stimulating factor (G-CSF) filgrastim sold as Neupogen from Amgen; pegfilgrastim sold as Neulasta
*alpha-glactosidase A Fabrazyme by Genzyme
*alpha-L-iduronidase (rhIDU; laronidase) Aldurazyme by BioMarin Pharmaceutical and Genzyme
*N-acetylgalactosamine-4-sulfatase (rhASB; galsulfase) Naglazyme (TM) by BioMarin Pharmaceutical
*DNAse Pulmozyme by Genentech
*Tissue plasminogen activator (TPA) Activase by Genentech
*Glucocerebrosidase Ceredase by Genzyme
*Interferon (IF) Interferon-beta-1a as Avonex from Biogen Idec; Rebif from Serono; Interferon beta-1b as Betaseron from Schering
*Insulin-like growth factor 1 (IGF-1)
Animal recombinants
*Bovine somatotropin (bST)
*Porcine somatotropin (pST)
*Bovine Chymosin
Viral recombinants
*Envelope protein of the hepatitis B virus marketed as Engerix-B by SmithKline Beecham
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