Artificial organ

An artificial organ is a man-made device that is implanted into, or integrated onto, a human to replace a natural organ, for the purpose of restoring a specific function or a group of related functions so the patient may return to as normal a life as possible. The replaced function doesn't necessarily have to be related to life support, but often is.

Implied by this definition is the fact that the device must not be continuously tethered to a stationary power supply, or other stationary resources, such as filters or chemical processing units. (Periodic rapid recharging of batteries, refilling of chemicals, and/or cleaning/replacing of filters, would exclude a device from being called an artificial organ.) Thus a dialysis machine, while a very successful and critically important life support device that completely replaces the duties of a kidney, is not an artificial organ. At this time a successful portable self-contained artificial kidney has not become available.

Reasons to construct and install an artificial organ, an extremely expensive process initially, which may entail many years of ongoing maintenance services not needed by a natural organ, might include:

* Life support to prevent imminent death while awaiting a transplant (e.g. artificial heart)
* Dramatic improvement of the patient's ability for self care (e.g. artificial limb)
* Improvement of the patient's ability to interact socially (e.g. cochlear implant)
* Cosmetic restoration after cancer surgery or accident

The use of any artificial organ by humans is almost always preceded by extensive experiments with animals. Initial testing in humans is frequently limited to those either already facing death, or who have exhausted every other treatment possibility. (Rarely testing may be done on healthy volunteers who are scheduled for execution pertaining to violent crimes.)

Although not typically thought of as organs, one might also consider replacement bone, and joints thereof, such as hip replacements, in this context.

Successful Restorations

There are now many artificial organs that have been implanted in humans, with varying degrees of success.

Brain pacemaker

These devices, including deep brain stimulators, send electrical impulses to the brain in order to relieve depression, epilepsy, tremors of Parkinson's disease, and other conditions. Rather than replacing existing neural networks to restore function, these devices often serve by disrupting the output of existing malfunctioning nerve centers to eliminate symptoms.

Artificial cardia

This pertains to gastric repairs, specifically of the valves at either end of the stomach. Artificial cardia can be used to fight, between other diseases, esophageal cancer, achalasia and gastroesophageal reflux disease.

= Artificial corpora cavernosa =

To treat erectile disfunction, both corpora cavernosa can be irreversibly surgically replaced with manually inflatable penile implants. This is a drastic therapeutic surgery meant only for men suffering from complete impotence that has resisted all other treatment approaches.

An implanted pump in the (groin) or (scrotum) can be manipulated by hand to fill these artificial cylinders, normally sized to be direct replacements for the natural corpus cavernosa, from an implanted reservoir in order to achieve an erection.

Artificial ear

For external cosmetic repair see Plastic Surgery.

For internal restoration of auditory function see Cochlear implant. While natural hearing, to the level of musical quality, is not typically achieved, most recipients are pleased, with some finding it useful enough to return to their surgeon with a request to do the other ear.

Artificial eye

The most successful function-replacing artificial eye so far is actually an external miniature digital camera with a remote unidirectional electronic interface implanted on the retina, optic nerve, or other related locations inside the brain. The present state of the art yields only very partial functionality, such as recognizing levels of brightness, swatches of color, and/or basic geometric shapes, proving the concept's potential. While the living eye is indeed a camera, it is also much more than that.

As explained in the main article about the retina, various researchers have demonstrated that the retina performs strategic image preprocessing for the brain. The problem of creating a 100% functional artificial electronic eye is even more complex than what is already obvious. Steadily increasing complexity of the artificial connection to the retina, optic nerve or related brain areas advances, combined with ongoing advances in computer science, is expected to dramatically improve the performance of this technology.

For the person whose damaged or diseased living eye retains some function, other options superior to the electronic eye described above may be available, as explained in the main article Visual prosthetic.

None of the current devices presents the cosmetic appearance of a living eye. For the nonfunctional cosmetic artificial eye, generically a "glass" eye, please see instead Ocular prosthetic.

Heart

Artificial heart

While considered a success, the use of artificial hearts is limited to patients awaiting transplants whose death is imminent. The current state of the art devices are unable to "reliably" sustain life beyond about 18 months.

= Artificial Pacemakers =

These electronic devices, which can either intermittently augment (defibrillator mode), continuously augment, or completely bypass the natural living cardiac pacemaker as needed, are so successful, they have become commonplace.

Artificial limbs

Artificial arms with semi-functional hands, some even fitted with working opposable "thumbs" plus 2 "fingers", and legs with shock absorbing feet capable of allowing a trained patient to even run, have become available. While the meaning of "full mobility" is debated, steady progress is made, as described in the main article Prosthesis.

Artificial liver

HepaLife is developing the first-of-its-kind bioartificial liver device intended for the treatment of liver failure using the Company’s patented PICM-19 liver stem cell line. The HepaLife bioartificial liver, currently under development, is designed to serve as a supportive device, either allowing the liver to regenerate upon acute liver failure, or to bridge the patient's liver functions until a transplant is available [ [http://www.hepalife.com/artificial_liver.php#liver HepaLife - Artificial Liver ] ] . It is only made possible by the fact that it uses real liver cells, and even then, it is not a permanent substitute for a liver.

On the other hand, Researchers Dr. Colin McGucklin, Professor of Regenerative Medicine at Newcastle University, and Dr. Nico Forraz, Senior Research Associate and Clinical Sciences Business Manager at Newcastle University, say that pieces of artificial liver could be used to repair livers injured in the next five years. These artificial livers could also be used outside the body in a manner analogous to the dialysis process used to keep alive patients whose kidneys have failed. [ [http://www.dailymail.co.uk/news/article-413551/British-scientists-grow-human-liver-laboratory.html British scientists grow human liver in a laboratory | Mail Online ] ] [ [http://www.livescience.com/health/061031_artif_liver.html World's First Artificial Human Liver Grown In Lab | LiveScience ] ]

Artificial lungs

With some almost fully functional, artificial lung promise to be a great success in near future.

Artificial pancreas

For the treatment of diabetes, numerous promising techniques are currently being tested, including some that incorporate donated living tissue housed in special materials to prevent the patient's immune system from killing the foreign live components.

Artificial urinary bladder

This represents a unique success in that these are autologous laboratory-grown living replacements, as opposed to most other artificial organs which depend upon electro-mechanical contrivances, and may or may not incorporate any living tissue.

Beyond Restoration

It is also possible to construct and install an artificial organ to give its possessor abilities which are not naturally occurring. Research is proceeding, particularly in areas of vision, memory, and information processing, however this idea is still in its infancy.

Some current research focuses on restoring inoperative short-term memory in accident victims and lost access to long-term memory in dementia patients. Success here would lead to widespread interest in applications for persons whose memory is considered healthy to dramatically enhance their memory of far beyond what can be achieved with mnemonic techniques. Given that our understanding of how living memory actually works is incomplete, it is unlikely this scenario will become reality in the near future.

One area of success was achieved in 2002 when a British Scientist, Kevin Warwick, had an array of 100 electrodes fired in to his nervous system in order to link his nervous system into the internet. With this in place he carried out a series of experiments including extending his nervous system over the internet to control a robotic hand, a form of extended sensory input and the first direct electronic communication between the nervous systems of two humans [Warwick,K, Gasson,M, Hutt,B, Goodhew,I, Kyberd,P, Schulzrinne,H and Wu,X: “Thought Communication and Control: A First Step using Radiotelegraphy”, IEE Proceedings on Communications, 151(3), pp.185-189, 2004] .

Another idea with significant consequences is that of implanting a Language Translator for diplomatic and military applications. While machine translation does exist, it is presently neither good nor small enough to fulfill its promise.

This might also include the existing (and controversial when applied to humans) practice of implanting subcutaneous "chips" (integrated circuits) for identification and location purposes. An example of this is the RFID tags made by VeriChip Corporation.

References

ee also

* Bionics
* Cochlear implant
* Organ (anatomy)
* Prosthesis
* Open source hardware
* Organ transplant

External links

* [http://www.asaio.com American Society for Artificial Internal Organs (ASAIO)]
* [http://www.intota.com/multisearch.asp?strSearchType=all&strQuery=artificial+organ Artificial organ experts]
* [http://www.usc.edu/dept/engineering/CNE/research/hipp/ Hardware Models of Hippocampus: Toward Brain Implants as Neural Prostheses for Memory Loss]
* [http://www.usc.edu/dept/engineering/CNE/research/opt/ Adaptive Optoelectronic Eye: Hybrid Sensor/Processor Architecture]
* [http://www.liver-products.com/liver-therapy/extracorporeal-liver-support-therapy.html/ Information on extracorporeal liver support]