- Olah reagent
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The Olah reagent is a nucleophilic fluorinating agent. It consists of a mixture of 70% hydrogen fluoride and 30% pyridine; alcohols react with this reagent to give alkyl fluorides:
It acts as a stabilized, less volatile form of hydrogen fluoride. It's used in the fluorination of steroids and in deprotection of peptides.[1][2][3] Instead of hydrogen fluoride, several other flourinating agents can be used, such as diethylaminosulfur trifluoride (DAST).
See also
- Ishikawa reagent
- Organofluoride
References
Categories:- Reagents for organic chemistry
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