O-succinylbenzoate—CoA ligase

o-succinylbenzoate-CoA ligase
Identifiers
EC number	6.2.1.26
CAS number	72506-70-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, an o-succinylbenzoate-CoA ligase (EC 6.2.1.26) is an enzyme that catalyzes the chemical reaction

ATP + o-succinylbenzoate + CoA $\rightleftharpoons$ AMP + diphosphate + o-succinylbenzoyl-CoA

The 3 substrates of this enzyme are ATP, o-succinylbenzoate, and CoA, whereas its 3 products are AMP, diphosphate, and o-succinylbenzoyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is 2-succinylbenzoate:CoA ligase (AMP-forming). Other names in common use include 2-succinylbenzoyl-coenzyme A synthetase, and 2-succinylbenzoate:CoA ligase (AMP-forming). This enzyme participates in ubiquinone biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2OKT and 2OLA.

References

• Heide L, Arendt S, Leistner E (1982). "Enzymatic synthesis, characterization, and metabolism of the coenzyme A ester of o-succinylbenzoic acid, an intermediate in menaquinone (vitamin K2) biosynthesis". J. Biol. Chem. 257 (13): 7396–400. PMID 7045104. 
• Kolkmann R, Leistner E (1987). "4-(2'-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis". Z. Naturforsch. [C]. 42 (11-12): 1207–14. PMID 2966501. 
• Meganathan R, Bentley R (1979). "Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes". J. Bacteriol. 140 (1): 92–8. PMC 216783. PMID 500558. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=216783. 

This ligase article is a stub. You can help Wikipedia by expanding it.v · Categories: Ligase stubs EC 6.2.1 Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Thematic stem Otaki, California Look at other dictionaries: O-succinylbenzoate-CoA ligase — In enzymology, an o succinylbenzoate CoA ligase (EC number|6.2.1.26) is an enzyme that catalyzes the chemical reaction:ATP + o succinylbenzoate + CoA ightleftharpoons AMP + diphosphate + o succinylbenzoyl CoAThe 3 substrates of this enzyme are… …   Wikipedia List of EC numbers (EC 6) — This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 6.1: Forming Carbon Oxygen… …   Wikipedia 18+ © Academic, 2000-2025 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”