Neo-organ

Neo-organ

In tissue engineering, neo-organ is a final structure of procedure based on transplantation of constructs consisting of endogenous stem/progenitor cells grown ex vivo within predesigned matrix scaffolds.[1] The scaffold eventually is resorbed, leaving transplanted cells and the stroma that they produce in the body.

References

  1. ^ Langer, R; Vacanti, J. (1993). "Tissue engineering". Science 260 (5110): 920–6. doi:10.1126/science.8493529. PMID 8493529. 

Further reading

  • Jayo, Manuel J; Jain, Deepak; Ludlow, John W; Payne, Richard; Wagner, Belinda J; McLorie, Gordon; Bertram, Timothy A (2008). "Long-term durability, tissue regeneration and neo-organ growth during skeletal maturation with a neo-bladder augmentation construct". Regenerative Medicine 3 (5): 671–82. doi:10.2217/17460751.3.5.671. PMID 18729792. 
  • Punzon, I.; Criado, LM; Serrano, A; Serrano, F; Bernad, A (2004). "Highly efficient lentiviral-mediated human cytokine transgenesis on the NOD/scid background". Blood 103 (2): 580–2. doi:10.1182/blood-2003-07-2298. PMID 14512303. 
  • Sanhadji, K; Grave, L; Touraine, JL; Leissner, P; Rouzioux, C; Firouzi, R; Kehrli, L; Tardy, JC et al. (2000). "Gene transfer of anti-gp41 antibody and CD4 immunoadhesin strongly reduces the HIV-1 load in humanized severe combined immunodeficient mice". AIDS 14 (18): 2813–22. doi:10.1097/00002030-200012220-00002. PMID 11153662. 
  • Yoo, J; Atala, A (1997). "A Novel Gene Delivery System Using Urothelial Tissue Engineered Neo-Organs". The Journal of Urology 158 (3 Pt 2): 1066–70. doi:10.1016/S0022-5347(01)64390-8. PMID 9258143. 
  • Rosenthal, FM; Köhler, G (1997). "Collagen as matrix for neo-organ formation by gene-transfected fibroblasts". Anticancer research 17 (2A): 1179–86. PMID 9137468. 
  • Moullier, Philippe; Maréchal, Valérie; Danos, Olivier; Heard, Jean Michel (1993). "Continuous systemic secretion of a lysosomal enzyme by genetically modified mouse skin fibroblasts". Transplantation 56 (2): 427–32. doi:10.1097/00007890-199308000-00034. PMID 8356601. 

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