NPTX1

Neuronal pentraxin I
Identifiers
Symbols	NPTX1; DKFZp686J2446; MGC105123; NP1
External IDs	OMIM: 602367 MGI: 107811 HomoloGene: 1891 GeneCards: NPTX1 Gene
Gene Ontology Molecular function • metal ion binding Cellular component • transport vesicle • cytoplasmic vesicle Biological process • transport • synaptic transmission • central nervous system development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4884	18164
Ensembl	ENSG00000171246	ENSMUSG00000025582
UniProt	Q15818	Q62443
RefSeq (mRNA)	NM_002522	NM_008730.2
RefSeq (protein)	NP_002513	NP_032756.1
Location (UCSC)	Chr 17: 78.44 – 78.45 Mb	Chr 11: 119.4 – 119.41 Mb
PubMed search	[1]	[2]

Neuronal pentraxin-1 (NP1) is a protein that in humans is encoded by the NPTX1 gene.^[1][2]

Function

NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.^[2]

References

1. ^ Omeis IA, Hsu YC, Perin MS (September 1996). "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization". Genomics 36 (3): 543–5. doi:10.1006/geno.1996.0503. PMID 8884281. 
2. ^ ^{a b} "Entrez Gene: neuronal pentraxin I". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4884. 

Further reading

• Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2.". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Abad MA, Enguita M, DeGregorio-Rocasolano N, et al. (2006). "Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain.". J. Neurosci. 26 (49): 12735–47. doi:10.1523/JNEUROSCI.0575-06.2006. PMID 17151277. 
• Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain.". Neuron 29 (2): 429–39. doi:10.1016/S0896-6273(01)00216-1. PMID 11239433. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Poulsen TT, Pedersen N, Perin MS, et al. (2005). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin.". Lung Cancer 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696. 
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.