NEGR1

Neuronal growth regulator 1
Identifiers
Symbols	NEGR1; DMML2433; IGLON4; KILON; MGC46680; Ntra
External IDs	OMIM: 613173 MGI: 2444846 HomoloGene: 41447 GeneCards: NEGR1 Gene
Gene Ontology Molecular function • vascular endothelial growth factor receptor activity • protein binding • ATP binding Cellular component • plasma membrane • dendrite • anchored to membrane • neuronal cell body Biological process • cell adhesion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	257194	320840
Ensembl	ENSG00000172260	ENSMUSG00000040037
UniProt	Q7Z3B1	Q80Z24
RefSeq (mRNA)	NM_173808	NM_177274
RefSeq (protein)	NP_776169	NP_796248
Location (UCSC)	Chr 1: 71.87 – 72.75 Mb	Chr 3: 156.22 – 156.98 Mb
PubMed search	[1]	[2]

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene.^[1]

Clinical significance

Variants of the NEGR1 gene may be associated with obesity.^[2][3][4]

References

1. ^ Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S (March 1999). "Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family". J. Biol. Chem. 274 (12): 8224–30. doi:10.1074/jbc.274.12.8224. PMID 10075727. 
2. ^ Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260. 
3. ^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC 2695662. PMID 19079261. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2695662. 
4. ^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The Role of Obesity-associated Loci Identified in Genome-wide Association Studies in the Determination of Pediatric BMI". Obesity (Silver Spring) 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782. PMID 19478790. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2860782. 

Further reading

• Elortza F, Mohammed S, Bunkenborg J, et al. (2006). "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment.". J. Proteome Res. 5 (4): 935–43. doi:10.1021/pr050419u. PMID 16602701. 
• Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study.". Obesity (Silver Spring) 18 (6): HASH(0x24fbeb0). doi:10.1038/oby.2009.413. PMID 19910938. 
• Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.". Am. J. Clin. Nutr. 91 (1): 184–90. doi:10.3945/ajcn.2009.28403. PMID 19812171. 
• Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2): 695–9. doi:10.1002/ajmg.b.31026. PMID 19746409. 
• Renström F, Payne F, Nordström A, et al. (2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.". Hum. Mol. Genet. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC 2664142. PMID 19164386. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2664142. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.". Am. J. Clin. Nutr. 90 (4): 951–9. doi:10.3945/ajcn.2009.27781. PMID 19692490. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Hom G, Graham RR, Modrek B, et al. (2008). "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.". N. Engl. J. Med. 358 (9): 900–9. doi:10.1056/NEJMoa0707865. PMID 18204098. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Yang Q, Kathiresan S, Lin JP, et al. (2007). "Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.". BMC Med. Genet. 8 Suppl 1: S12. doi:10.1186/1471-2350-8-S1-S12. PMC 1995619. PMID 17903294. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1995619. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population.". J. Hum. Genet. 54 (12): 727–31. doi:10.1038/jhg.2009.106. PMID 19851340. 
• Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260.