Thymectacin

Thymectacin: Thymectacin

Systematic (IUPAC) name

(2S)-methyl 2-((((2R,3S,5R)-5-(5-((E)-2-bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate

Clinical data

Pregnancy cat. ?

Legal status ?

Identifiers

CAS number 232925-18-7

ATC code ?

PubChem CID 6440764

Chemical data

Formula C₂₁H₂₅Br N₃O₉P

Mol. mass 574.3185 g/mol

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Thymectacin (NB-1011, NB-101, N-[[5-[(E)-2-Bromovinyl]-2'-deoxyuridin-5'-O-yl](phenoxy)phosphoryl]-L-alanine methyl ester) is an anticancer prodrug of brivudine monophosphate. It developed by New Biotics and it has entered in phase I clinical trials for colon cancer.^[1]

References

^ Wilson, RH (2006). "Novel Therapeutic Developments Other Than EGFR and VEGF Inhibition in Colorectal Cancer". The Oncologist 11 (9): 1018–1024. doi:10.1634/theoncologist.11-9-1018. PMID 17030644. http://theoncologist.alphamedpress.org/cgi/content/full/11/9/1018.

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Systematic (IUPAC) name
(2S)-methyl 2-((((2R,3S,5R)-5-(5-((E)-2-bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	232925-18-7
ATC code	?
PubChem	CID 6440764
Chemical data
Formula	C₂₁H₂₅Br N₃O₉P
Mol. mass	574.3185 g/mol
Y(what is this?) (verify)