MTRF1L

MTRF1L
Mitochondrial translational release factor 1-like
Identifiers
Symbols MTRF1L; HMRF1L; MGC102748; MRF1L; mtRF1a
External IDs OMIM: 613542 HomoloGene: 5905 GeneCards: MTRF1L Gene
Orthologs
Species Human Mouse
Entrez 54516 108853
Ensembl ENSG00000112031 ENSMUSG00000019774
UniProt Q9UGC7 Q8BJU9
RefSeq (mRNA) n/a NM_175374.3
RefSeq (protein) n/a NP_780583.1
Location (UCSC) Chr 6:
153.31 – 153.32 Mb		 Chr 10:
4.52 – 4.53 Mb
PubMed search [1] [2]
This box: view · protein that in humans is encoded by the MTRF1L gene.[1]

Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM].[1]

References

  1. ^ a b "Entrez Gene: Mitochondrial translational release factor 1-like". http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=54516. Retrieved 2011-09-20T14:56:56.703-07:00. 

Further reading

Soleimanpour-Lichaei, H. R.; Kühl, I.; Gaisne, M.; Passos, J. F.; Wydro, M.; Rorbach, J.; Temperley, R.; Bonnefoy, N. et al. (2007). "MtRF1a is a Human Mitochondrial Translation Release Factor Decoding the Major Termination Codons UAA and UAG". Molecular Cell 27 (5): 745–757. doi:10.1016/j.molcel.2007.06.031. PMC 1976341. PMID 17803939. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1976341.  edit Nozaki, Y.; Matsunaga, N.; Ishizawa, T.; Ueda, T.; Takeuchi, N. (2008). "HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG". Genes to Cells 13 (5): 429–438. doi:10.1111/j.1365-2443.2008.01181.x. PMID 18429816.  edit Ishizawa, T.; Nozaki, Y.; Ueda, T.; Takeuchi, N. (2008). "The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC". Biochemical and Biophysical Research Communications 373 (1): 99–103. doi:10.1016/j.bbrc.2008.05.176. PMID 18541145.  edit Vieira, A. R.; McHenry, T. G.; Daack-Hirsch, S.; Murray, J. C.; Marazita, M. L. (2008). "Candidate Gene/Loci Studies in Cleft Lip/Palate and Dental Anomalies Finds Novel Susceptibility Genes for Clefts". Genetics in Medicine 10 (9): 668–674. doi:10.1097/GIM.0b013e3181833793. PMC 2734954. PMID 18978678. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734954.  edit Antonicka, H.; Østergaard, E.; Sasarman, F.; Weraarpachai, W.; Wibrand, F.; Pedersen, A. M. B.; Rodenburg, R. J.; Van Der Knaap, M. S. et al. (2010). "Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect". The American Journal of Human Genetics 87 (1): 115–122. doi:10.1016/j.ajhg.2010.06.004. PMC 2896764. PMID 20598281. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896764.  edit


Wikimedia Foundation. 2010.

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”