Marcus Raichle

Marc Raichle

Marcus Raichle is a neurologist at the Washington University School of Medicine in Saint Louis. He is a professor in the Department of Radiology with joint appointments in Neurology, Neurobiology and Biomedical Engineering. His research over the past 40 years has focused on the nature of functional brain imaging signals arising from PET and fMRI and the application of these techniques to the study of the human brain in health and disease.^[1]

Career

Noteworthy accomplishments during this time have been the discovery of the relative independence of blood flow and oxygen consumption during changes in brain activity which provided the physiological basis of fMRI ^[2] ; the discovery of a default mode of brain function (i.e., organized intrinsic activity) and its signature system, the brain’s default mode network^[3]; and, the discovery that aerobic glycolysis contributes to brain function independent of oxidative phosphorylation^[4][5].

Works

• Zhang, D; Snyder AZ, Shimony JS, Fox MD, Raichle ME (2010). "Noninvasive functional and structural connectivity mapping of the human thalamocortical system". Cerebral Cortex 20 (5): 1187–1194. doi:10.1093/cercor/bhp182. PMC 2852505. PMID 19729393. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2852505. 

• Fair, DA; Bathula D, Mills KL, Costa Dias TG, Blythe MS, Zhang D, Snyder AZ, Raichle ME, Stevens AA, Nigg JT, Nagel BJ (2010). "thalamocortical functional connectivity across development". Frontiers in Systems Neuroscience 4: 1–10. doi:10.3389/fnsys.2010.00010. PMC 2876871. PMID 20514143. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2876871. 

• He, BJ; Zempel JM, Snyder AZ, Raichle ME (2010). "The temporal structures and functional significance of scale-free brain activity". Neuron 66 (3): 353–369. doi:10.1016/j.neuron.2010.04.020. PMC 2878725. PMID 20471349. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2878725. 

• Raichle, ME (2010). "Two views of brain function". Trends in Cognitive Science 14 (4): 180–190. doi:10.1016/j.tics.2010.01.008. PMID 20206576. 

• Raichle, ME (2010). "The brain's dark energy". Scientific American 302 (3): 28–33. PMID 20184182. 

• Paul, BM; Snyder AZ, Haist F, Raichle ME, Bellugi U, Stiles J (2009). "Amygdala response to faces parallels social behavior in Williams syndrome". Social Cognitive and Affective Neuroscience 4 (3): 278–285. doi:10.1093/scan/nsp023. PMC 2728637. PMID 19633063. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2728637. 

• Zhang, D; Raichle ME (2010). "Disease and the brain's dark energy". Nature Reviews Neurology 6 (1): 15–28. doi:10.1038/nrneurol.2009.198. PMID 20057496. 

• Sheline, YI; Raichle ME, Snyder AZ, Morris JC, Head D, Wang S. Mintun MA (2010). "Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly". J. Biological Psychiatry 67 (6): 584–587. doi:10.1016/j.biopsych.2009.08.024. PMC 2829379. PMID 19833321. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2829379. 

• Raichle, ME (2009). "A paradigm shift in functional brain imaging". J. Neuroscience 29 (41): 12729–12734. doi:10.1523/JNEUROSCI.4366-09.2009. PMID 19828783. 

• White, BR; Snyder AZ, Cohen AL, Petersen SE, Raichle ME, Schlaggar BL, Culver JP (2009). "Resting-state functional connectivity in the human brain revealed with diffuse optical tomography". NeuroImage 47 (1): 148–156. doi:10.1016/j.neuroimage.2009.03.058. PMC 2699418. PMID 19344773. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2699418. 

• He, BJ; Raichle ME (2009). "The fMRI signal, slow cortical potentials and consciousness". Trends in Cognitive Science 13 (7): 302–309. doi:10.1016/j.tics.2009.04.004. PMC 2855786. PMID 19535283. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2855786. 

Affiliations

Professional memberships

• Member: National Academy of Sciences, Institute of Medicine, American Academy of Arts and Sciences.
• Fellow: American Association Advancement of Science.

Professional societies

• Society for Neuroscience
• American Neurological Association
• American Academy Neurology
• International Society Cerebral Blood Flow & Metabolism.

References

1. ^ "Academy Members". http://academyofsciencestl.org/initiatives/fellows/r/marcus_raichle.php. 
2. ^ Petersen, SE; Fox PT, Posner MI, Mintun M, Raichle ME (1988). "Positron emission tomographic studies of the cortical anatomy of single-word processing". Nature 331 (6157): 585–589. doi:10.1038/331585a0. PMID 3277066. 
3. ^ Fox, MD; Zhang D, Snyder DZ, Raichle ME (2009). "The global signal and observed anticorrelated resting state brain networks". J. Neurophysiology 101 (6): 3270–3283. doi:10.1152/jn.90777.2008. PMC 2694109. PMID 19339462. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2694109. 
4. ^ Vaishnavi, SN; Vlassenko AG, Rundle MM, Snyder AZ, Mintun MA, Raichle ME (2010). "Regional aerobic glycolysis in the human brain". PNAS 107 (41): 17757–17762. doi:10.1073/pnas.1010459107. PMC 2955101. PMID 20837536. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2955101. 
5. ^ Vlassenko, AG; Vaishnavi SN, Couture L, Sacco D, Shannon BJ, Mac, RH, Morris JC, Raichle ME, Mintun MA (2010). "Spatial correlation between brain aerobic glycolysis and amyloid-β deposition". PNAS 107 (41): 17763–17767. doi:10.1073/pnas.1010461107. PMC 2955133. PMID 20837517. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2955133. 

External links

• Official site

Persondata
Name	Raichle, Marcus E.
Alternative names	Raichle, Marc
Short description	Neuroscientist
Date of birth	March 15, 1937
Place of birth	Hoquiam, Washington
Date of death
Place of death