Pro-hevein

Pro-hevein
Pro-hevein
Identifiers
Symbol  ?
CAS number 137295-60-4
UniProt P02877
Other data

Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced[1] and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation of latex.[2]

The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain (also known as CBM18 carbohydrate-binding module) that binds to chitin and a 138 amino-acid Win-like protein bearing a Barwin domain.

It has antifungal properties.[3]

Role of hevein in latex allergy

Hevein is the main IgE-binding epitope of the major latex allergen prohevein[4] as are hevein-like protein domains in fruit class I chitinases.[5] Therefore it is a possible cause for allergen cross-reactivity between latex and banana[6] or other fruits like chestnuts or avocadoes.[7] Hevein-like genes can be found in many plants including Arabidopsis.[8]

The conformational epitope on hevein is called Hev b 6.02.[9][10]

References

  1. ^ Wound-induced accumulation of mRNA containing a hevein sequence in laticifers of rubber tree (Hevea brasiliensis). I Broekaert, H I Lee, A Kush, N H Chua and N Raikhel, PNAS, October 1, 1990 vol. 87 no. 19, pages 7633-7637
  2. ^ Hevein, a lectin-like protein from Hevea brasiliensis (rubber tree) is involved in the coagulation of latex. X Gidrol, H Chrestin, H L Tan and A Kush, The Journal of Biological Chemistry, March 25, 1994, 269, pages 9278-9283
  3. ^ Hevein: an antifungal protein from rubber-tree (Hevea brasiliensis) latex. Jan Parijs, Willem F Broekaert, Irwin J Goldstein and Willy J Peumans, Planta, 1991, 183 (2), pages 258-264
  4. ^ The main IgE-binding epitope of a major latex allergen, prohevein, is present in its N-terminal 43-amino acid fragment, hevein. H Alenius, N Kalkkinen, T Reunala, K Turjanmaa and T Palosuo, The Journal of Immunology, February 15, 1996, vol. 156, no. 4, pages 1618-1625
  5. ^ What is the role of the hevein-like domain of fruit class I chitinases in their allergenic capacity? Dìaz-Perales A, Sánchez-Monge R, Blanco C, Lombardero M, Carillo T and Salcedo G, Clin Exp Allergy. 2002 Mar;32(3), pages 448-454, PubMed
  6. ^ Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana. Mikkola JH, Alenius H, Kalkkinen N, Turjanmaa K, Palosuo T and Reunala T.J, Allergy Clin Immunol. 1998 Dec, 102(6 Pt 1), pages 1005-1012, PubMed, doi:10.1046/j.1365-2222.2002.01306.x
  7. ^ Class I chitinases with hevein-like domain, but not class II enzymes, are relevant chestnut and avocado allergens. Diaz-Perales A, Collada C, Blanco C, Sánchez-Monge R, Carrillo T, Aragoncillo C and Salcedo G, J Allergy Clin Immunol. 1998 Jul, 102(1), pages 127-133, PubMed
  8. ^ Regulation of a hevein-like gene in Arabidopsis. Potter S, Uknes S, Lawton K, Winter AM, Chandler D, DiMaio J, Novitzky R, Ward E and Ryals J, Mol Plant Microbe Interact. 1993 Nov-Dec, 6(6), pages 680-685, PubMed
  9. ^ Insights into a conformational epitope of Hev b 6.02 (hevein). Reyes-López CA, Hernández-Santoyo A, Pedraza-Escalona M, Mendoza G, Hernández-Arana A and Rodríguez-Romero A, Biochem Biophys Res Commun. 2004 Jan 30, 314(1), pages 123-130, PubMed
  10. ^ Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies. Martha Pedraza-Escalona, Baltazar Becerril-Luján, Concepción Agundis, Lenin Domínguez-Ramírez, Ali Pereyra, Lidia Riaño-Umbarila and Adela Rodríguez-Romero, Molecular Immunology, Volume 46, Issue 4, February 2009, Pages 668-676, doi:10.1016/j.molimm.2008.08.282

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