Diaminopyrimidine

Diaminopyrimidines are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.

Iclaprim

Trimethoprim

They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim ^[1] and the antibiotics Iclaprim and trimethoprim).

Some have been patented as anti-cancer drugs.^[2]

See also

• 2,4-Diaminopyrimidine
• 4,5-Diaminopyrimidine

References

1. ^ http://aac.asm.org/cgi/content/full/45/12/3293 "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001
2. ^ http://www.wipo.int/pctdb/en/wo.jsp?IA=GB1998000111&DISPLAY=DESC

This article about an organic compound is a stub. You can help Wikipedia by expanding it.v · Categories: Pyrimidines Aromatic amines Organic compound stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат 2,6-Diaminopurine 2,5-Diaminotoluene Look at other dictionaries: Diaminopyrimidine — Name 2,4 Diaminopyrimidin 2,5 Diaminopyrimidin 4,5 Diaminopyrimidin 4,6 Diaminopyrimidin Andere Namen Pyrimidin 2,4 diamin Pyrimidin 2,5 diamin Pyrimidin 4,5 diamin Pyrimidin 4,6 diamin Strukturformel …   Deutsch Wikipedia Diaminopyrimidine — Les diaminopyrimidines sont des antibactériens de synthèse, bactériostatiques. Le triméthoprime est une diaminopyrimidine. Il n est jamais utilisé seul, on l associe aux sulfamides antibactériens. L association est synergique. La sulfadoxine est… …   Wikipédia en Français diaminopyrimidine — noun a) Any of four isomeric diamino derivatives of pyrimidine b) Any of a class of drugs containing such a moiety …   Wiktionary Diaminopyrimidin — Diaminopyrimidine sind basische Verbindungen, die als Folsäureantagonist wirken. Sie blockieren also die Synthese von Folsäure innerhalb eines Bakteriums. Folsäure ist für viele Bakterien ein wichtiger Wuchsstoff. Vertreter dieser Gruppe sind zum …   Deutsch Wikipedia Iclaprim — Strukturformel Allgemeines Freiname Iclaprim Andere Namen …   Deutsch Wikipedia Pteridine — Pteridin, die Stammverbindung der Pteridine Als Pteridine bezeichnet man Derivate des Stammheterocyclus Pteridin. Darunter fallen biologisch wichtige Moleküle, so Folsäure und Biopterin. In den Flavinen findet man eine benzo anellierte Pteridin… …   Deutsch Wikipedia 2,4-DAP — Strukturformel Allgemeines Name 2,4 Diaminopyrimidin Andere Namen 2,4 DAP, Pyrimid …   Deutsch Wikipedia 2,4-Diaminopyrimidin — Strukturformel Allgemeines Name 2,4 Diaminopyrimidin Ande …   Deutsch Wikipedia Pyrimidin-2,4-diyldiamin — Strukturformel Allgemeines Name 2,4 Diaminopyrimidin Andere Namen 2,4 DAP, Pyrimidin 2,4 …   Deutsch Wikipedia Iclaprim — Drugbox IUPAC name = 5 [(2 cyclopropyl 7,8 dimethoxy 2 H chromen 5 yl)methyl] pyrimidine 2,4 diamine CAS number = 192314 93​ 5 ATC prefix = ATC suffix = PubChem = 213043 DrugBank = C=19 |H=22 |N=4 |O=3 molecular weight = 354.403 g/mol smiles =… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”