Diacylglycerol—sterol O-acyltransferase

Diacylglycerol—sterol O-acyltransferase
diacylglycerol-sterol O-acyltransferase
Identifiers
EC number 2.3.1.73
CAS number 79586-23-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diacylglycerol-sterol O-acyltransferase (EC 2.3.1.73) is an enzyme that catalyzes the chemical reaction

1,2-diacyl-sn-glycerol + sterol \rightleftharpoons monoacylglycerol + sterol ester

Thus, the two substrates of this enzyme are 1,2-diacyl-sn-glycerol and sterol, whereas its two products are monoacylglycerol and sterol ester.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is 1,2-diacyl-sn-glycerol:sterol O-acyltransferase. This enzyme is also called 1,2-diacyl-sn-glycerol:sterol acyl transferase. This enzyme participates in bile acid biosynthesis.

References

  • Bartlett K, Keat MJ and Mercer EI (1974). "Biosynthesis of sterol esters in Phycomyces blakesleeanus". Phytochemistry 13: 1107–1113. doi:10.1016/0031-9422(74)80083-X. 
  • Garcia RE, Mudd JB (1978). "Metabolism of monoacylglycerol and diacylglycerol by enzyme preparations from spinach leaves". Arch. Biochem. Biophys. 191 (2): 487–93. doi:10.1016/0003-9861(78)90387-9. PMID 742884. 
  • Garcia RE and Mudd JB (1981). "1,2-Diacyl-sn-glycerol:sterol acyl transferase from spinach leaves (Spinacia oleracea L.)". Methods Enzymol. 71: 768–772. doi:10.1016/0076-6879(81)71090-5. 
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