Delta atracotoxin

Delta Atracotoxin
Identifiers
Symbol	Atracotoxin
Pfam	PF05353
InterPro	IPR008017
SCOP	1qdp
OPM protein	1vtx
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Robustoxin (δ-ACTX-Ar1), sometimes misspelled robustotoxin, and alternatively known as delta atracotoxin, is a low-molecular-weight neurotoxic polypeptide found in the venom of the Sydney funnel-web spider (Atrax robustus).

Delta atracotoxin produces potentially fatal neurotoxic symptoms in primates by slowing the inactivation of sodium ion channels in autonomic and motor neurons. In the spiders' intended insect prey, the toxin exerts this same activity upon potassium and calcium ion channels.^[1].

The structure of atracotoxin comprises a core beta region with a cystine knot motif, a feature seen in other neurotoxic polypeptides^[1].

References

1. ^ ^{a b} Mackay JP, King GF, Fletcher JI, Chapman BE, Howden ME (1997). "The structure of versutoxin (delta-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel". Structure 5 (11): 1525–1535. doi:10.1016/S0969-2126(97)00301-8. PMID 9384567. 

External links

• Structure of robustoxin