DCHS1

Dachsous 1 (Drosophila)
Identifiers
Symbols	DCHS1; CDH25; CDHR6; FIB1; FLJ11790; KIAA1773; PCDH16
External IDs	OMIM: 603057 MGI: 2685011 HomoloGene: 2771 GeneCards: DCHS1 Gene
Gene Ontology Molecular function • calcium ion binding Cellular component • plasma membrane • membrane • integral to membrane Biological process • cell adhesion • homophilic cell adhesion • calcium-dependent cell-cell adhesion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8642	233651
Ensembl	ENSG00000166341	ENSMUSG00000036862
UniProt	Q96JQ0	Q6PAS4
RefSeq (mRNA)	NM_003737	NM_001162943.1
RefSeq (protein)	NP_003728	NP_001156415.1
Location (UCSC)	Chr 11: 6.64 – 6.68 Mb	Chr 7: 112.9 – 112.94 Mb
PubMed search	[1]	[2]

Protein dachsous homolog 1, also known as protocadherin-16 (PCDH16) or cadherin-19 (CDH19) or cadherin-25 (CDH25) or fibroblast cadherin-1 (FIB1), is a protein that in humans is encoded by the DCHS1 gene.^[1][2]

Function

This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing.^[1]

References

1. ^ ^{a b} "Entrez Gene: dachsous 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8642. 
2. ^ Matsuyoshi N, Imamura S (June 1997). "Multiple cadherins are expressed in human fibroblasts". Biochem. Biophys. Res. Commun. 235 (2): 355–8. doi:10.1006/bbrc.1997.6707. PMID 9199196. 

Further reading

• Rose JE, Behm FM, Drgon T, et al.. "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.". Mol. Med. 16 (7-8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2896464. 
• Nakajima D, Nakayama M, Kikuno R, et al. (2001). "Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs.". Brain Res. Mol. Brain Res. 94 (1-2): 85–95. doi:10.1016/S0169-328X(01)00218-2. PMID 11597768. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.