Cyclopentenone prostaglandin

Cyclopentenone prostaglandin (cyPG) is a type of prostaglandin, a molecule which regulates inflammation and other processes. It is a potential new target for anti-inflammatory actions. It is thought to prevent the inflammatory pathway by inhibiting the activation of NF-κB, a transcription factor in cell reproduction.

The cyclopentenone prostaglandin known as 15d-PGJ2 has been shown to inhibit a gene in T cells which is active in inflammation, such as in various autoimmune diseases.^[1][2]

References

1. ^ Fionda, C., et al. (2007). Inhibition of Trail gene expression by cyclopentenonic prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in T lymphocytes. Molecular Pharmacology 72:5 1246-57.
2. ^ Cernuda-Morollón, E., et al. (2001). 15-Deoxy-Δ12,14-prostaglandin J2 Inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit. Journal of Biological Chemistry 276 35530-36.

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.v · Categories: Prostaglandins Anti-inflammatory agents Musculoskeletal system drug stubs Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Cyclopentenone 8-Cyclopentyl-1,3-dimethylxanthine Look at other dictionaries: Cyclopentenone prostaglandins — Cyclopentenone Prostaglandin (cyPG) is a potential new target for anti inflammatory actions. It is thought to have the action of inhibit the IκB kinase which prevent the activation of NF κB, hence prevent the inflammatory pathway …   Wikipedia Progesterone — Systematic (IUPAC) name Pregn 4 ene 3,20 dione …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”