Cyclopentenone prostaglandin

Cyclopentenone prostaglandin (cyPG) is a type of prostaglandin, a molecule which regulates inflammation and other processes. It is a potential new target for anti-inflammatory actions. It is thought to prevent the inflammatory pathway by inhibiting the activation of NF-κB, a transcription factor in cell reproduction.

The cyclopentenone prostaglandin known as 15d-PGJ2 has been shown to inhibit a gene in T cells which is active in inflammation, such as in various autoimmune diseases.^[1][2]

References

1. ^ Fionda, C., et al. (2007). Inhibition of Trail gene expression by cyclopentenonic prostaglandin 15-Deoxy-Δ12,14-Prostaglandin J2 in T lymphocytes. Molecular Pharmacology 72:5 1246-57.
2. ^ Cernuda-Morollón, E., et al. (2001). 15-Deoxy-Δ12,14-prostaglandin J2 Inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit. Journal of Biological Chemistry 276 35530-36.

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