- Collagenous spherulosis
Collagenous spherulosis Classification and external resources
Micrograph of collagenous spherulosis with the characteristic histomorphology - intratubular eosinophilic material with a spoke-like arrangement. H&E stain.
Collagenous spherulosis, also mucinous spherulosis and simply spherulosis, is a benign finding in breast pathology. It is almost always an incidental finding, though it is occasionally associated with calcifications, which may lead to a biopsy.
Collagenous spherulosis is characterized by a tubular/cribriform architecture with intratubular eosinophilic material that classically is arranged like the spokes of a wheel ("radial spikes"). There is usually no mitotic activity, and two cells populations (epithelial & myoepithelial) are present, like in benign breast glands.
The lesions are typically small (less than 50 spherules per lesion, less than 100 micrometers in size) and may be multifocal.
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