- Pedunculopontine nucleus
Name = PAGENAME
Latin = nucleus tegmentalis pedunculopontinus
BrainInfoType = hier
BrainInfoNumber = 495
MeshName = Pedunculopontine+Tegmental+Nucleus
DorlandsPre = n_11
DorlandsSuf = 12583626
The pedunculopontine nucleus (PPN) (or pedunculopontine tegmental nucleus, PPTN) is located in the
brainstem, caudal to the substantia nigraand adjacent to the superior cerebellar peduncle. It is composed by a wide variety of neurochemical cell types, including cholinergic, glutamatergicand GABAergiccells. In the classical sense, the PPN is considered to be one of the main components of the reticular activating system.
One of the distinctive characteristics of the PPN is the wide range of its projections. PPN
neuronssend their axonsto several targets in the thalamus, basal ganglia, cerebral cortex, basal forebrain, and lower brainstem. A particularly interesting area for the study of PPN projections is the basal ganglia, due to the high level of interconnectivity between them. The complex receives direct afferences from the medial pallidum.
The PPN is involved in many functions, including
arousal, attention, learning, reward, and locomotion. It is also implicated in the generation and maintenance of REM sleep.
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