International Studies of Infarct Survival

International Studies of Infarct Survival

The International Studies of Infarct Survival (ISIS) were four randomized controlled trials of several drugs for treating suspected acute myocardial infarction ("heart attack"). More than 134,000 patients from over 20 countries took part in four large simple trials between 1981 and 1993, coordinated from Oxford, England.citation
last1 = Hennekens | first1 = Charles H.
year = 1998
title = Trials of Thrombolytic Therapy: the International Studies of Infarct Survival Experience
journal = Journal of Interventional Cardiology
volume = 11
pages = 1
doi = 10.1111/j.1540-8183.1998.tb00089.x] Citation
last = Hennekens | first = Charles H.
last2 = Skerrett | first2 = P.J.
year = 2005
title = International Studies of Infarct Survival (ISIS)
doi = 10.1002/0470011815.b2a01031
journal = Encyclopedia of Biostatistics]

ISIS-1

The First International Study of Infarct Survival (ISIS-1) was a placebo-controlled trial of the beta-blocker atenolol. It recruited 16,027 patients and was completed in 1985. [citation
year = 1986
author = ISIS-1 (Second International Study of lnfarct Survival) Collaborative Group
title = Randomised trial of intravenous atenolol among 16027 cases of suspected acute myocardialinfarction: ISIS-1
journal = The Lancet
volume = 328
pages = 57-66
doi = 10.1016/S0140-6736(88)92833-4]

ISIS-2

The Second International Study of Infarct Survival (ISIS-2) was a 2×2 factorial placebo-controlled trial of aspirin and the thrombolytic drug streptokinase. It recruited 17,187 patients and was completed in 1988. [citation
year = 1988
author = ISIS-2 (Second International Study of lnfarct Survival) Collaborative Group
title = Randomised Trial of Intravenous Streptokinase, Oral Aspirin, Both, or Neither Among 17 187 Cases of Suspected Acute Myocardial Infarction: ISIS-2
journal = The Lancet
volume = 332
pages = 349-360
doi = 10.1016/S0140-6736(88)92833-4]

ISIS-3

The Third International Study of Infarct Survival (ISIS-3) was a 3×2 factorial trial that compared the three thrombolytic drugs streptokinase, tissue plasminogen activator (tPA) and anistreplase to each other, and also compared the anticoagulant heparin to no heparin. All patients were also given aspirin. It recruited 41,299 patients and was completed in 1991.citation
author = ISIS-3 (Third International Study of lnfarct Survival) Collaborative Group
year = 1992
title = ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41 299 cases of suspected acute myocardial infarction
journal = The Lancet
volume = 339
pages = 753-770
doi = 10.1016/0140-6736(92)91893-D]

ISIS-4

The Fourth International Study of Infarct Survival (ISIS-4) was a 2×2×2 factorial placebo-controlled trial of the angiotensin-converting enzyme inhibitor (ACE inhibitor) captopril, mononitrate and magnesium sulphate. It recruited 58,050 patients and was completed in 1993.citation
author = ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group
year = 1995
title = ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction
journal = The Lancet
volume = 345
pages = 669-682
doi = 10.1016/S0140-6736(95)90865-X]

ee also

*GISSI
*Thrombolysis In Myocardial Infarction (TIMI)

References


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