Ion mobility spectrometry-mass spectrometry
- Ion mobility spectrometry-mass spectrometry
Ion mobility spectrometry-mass spectrometry (IMS-MS) is a method that combines the features of ion mobility spectrometry and mass spectrometry to identify different substances within a test sample.
History
On the one hand, ion mobility spectrometry was developed in the 70s and typically separates charged particles on a millisecond scale. On the other hand, time-of-flight mass spectrometry was developed in the 50s and typically separates charged particles on a microsecond scale.The combination of both instruments was pioneered in the end of the 90s at Indiana University by David E. Clemmer and co-workers [Henderson S C, Valentine S J, Counterman A E, Clemmer D E, "Anal. Chem." 1999, "71", (2), 291-301] [Hoaglund C S, Valentine S J, Sporleder C R, Reilly J P, Clemmer D E, "Anal. Chem." 1998, "70", (11), 2236-2242.] .
Instrumentation
The IMS-MS is composed of two major building blocks: the ion mobility spectrometer and the mass spectrometer. Whereas the ion mobility spectrometer is usually made of a drift region at atmospheric pressure or lower, the mass spectrometer is under a high vacuum.
Applications
The IMS-MS technique can be used in proteomics, for analyzing complex mixtures of peptides.
ee also
* Liquid chromatography-mass spectrometry
* Gas chromatography-mass spectrometry
References
External links
* [http://www.chem.arizona.edu/massspec/intro_html/intro.html Introduction to Mass Spectrometry]
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