Rodiasine

Rodiasine
Rodiasine
Identifiers
CAS number 6391-64-6
PubChem 442345
ChemSpider 390797 YesY
ChEBI CHEBI:8886 YesY
Jmol-3D images Image 1
Properties
Molecular formula C38H42N2O6
Molar mass 622.75 g/mol
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Rodiasine is an cyclic bisbenzylisoquinoline alkaloid that was first isolated from the South American greenheart tree Chlorocardium rodiei.[1] The synthesis of O-demethylrodiasine (antioquine) and its derivatives, and the possible application of these compounds as anti-cancer, calcium channel blockers, and anti-parasitic drugs has been described.[2][3]

References

  1. ^ Grundon, M.F.; McGarvey, J.E.B. (1966). "Alkaloids from greenheart. Part III. The structure of rodiasine. Mass spectra of bisbenzylisoquinoline alkaloids". Journal of the Chemical Society C: Organic 1966: 1082–1084. doi:10.1039/J39660001082. 
  2. ^ Bentley, K. W. (1996). "β-Phenylethylamines and the isoquinoline alkaloids". Natural Product Reports 13 (2): 127–150. doi:10.1039/NP9961300127. http://www.rsc.org/ejarchive/NP/1996/NP9961300127.pdf. 
  3. ^ D'Ocon MP, Candenas ML, Anselmi E, Zafra-Polo MC, Cortes D (1989). "Antioquine: a new bisbenzylisoquinoleine alkaloid with calcium antagonist activity". Arch Int Pharmacodyn Ther 297: 205–16. PMID 2730236.