Missouri Route 181

Route 181
Route information
Maintained by MoDOT
Length:	55 mi[citation needed] (89 km)
Major junctions
South end:	U.S. Route 160 in Gainesville
North end:	Business U.S. Route 60 in Cabool
Highway system
Missouri Highways Supplemental ← Route 180 Route 184 x20px →

Route 181 is a highway in southern Missouri. Its northern terminus is at Business U.S. Route 60 in Cabool; its southern terminus is at U.S. Route 160 in Gainesville.

The road intersects with Route 14 near the twin bridges. It runs concurrently with Route 14 westward for about 1-mile (1.6 km), then heads back south toward Dora. About three miles (5 km) south of Dora, near Highway CC, Route 181 heads west again toward the Hodgson and Zanoni mills, while Highway H continues southward toward US 160.