Tudor domain

A tudor domain is a conserved protein structural motif originally identified as a region of 50 amino acids found in the Tudor protein encoded in Drosophila. The structurally characterized Tudor domain in human SMN (survival of motor neuron) is a strongly bent anti-parallel β-sheet consisting of five β-strands with a barrel-like fold and recognizes symmetrically dimethylated arginine. [cite journal
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author = Remco Sprangers, Matthew R. Groves, Irmgard Sinning and Michael Sattler
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year = 2003
month = March
title = High-resolution X-ray and NMR Structures of the SMN Tudor Domain: Conformational Variation in the Binding Site for Symmetrically Dimethylated Arginine Residues
journal = Journal of Molecular Biology
volume = 327
issue = 2
pages = 507-520
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doi = 10.1016/S0022-2836(03)00148-7
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quote = ] The proteins TP53BP1 (Tumor suppressor p53-binding protein 1) and its fission yeast homolog Crb2 [cite journal
quotes = "...both 53BP1 and Crb2 contain tandem tudor domains that interact with histone H4 specifically dimethylated at Lys20 (H4-K20me2)."
author = Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G
date =
year = 2006
month = December
title = Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
journal = Cell
volume = 127
issue = 7
pages = 1361-1373
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doi = 10.1016/j.cell.2006.10.043
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quote = ] and JMJD2A (Jumonji domain containing 2A) contain either tandem or double Tudor domains and recognize methylated histones. [cite journal
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author = Huang Y, Fang J, Bedford MT, Zhang Y, Xu RM
date =
year = 2006
month = May
title = Recognition of Histone H3 Lysine-4 Methylation by the Double Tudor Domain of JMJD2A
journal = Science
volume = 312
issue = 5774
pages = 748 - 751
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doi = 10.1126/science.1125162
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quote = ] [cite journal
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author = Lee J, Thompson JR, Botuyan MV, Mer G
date =
year = 2008
month = January
title = Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor
journal = Nature Structural & Molecular Biology
volume = 15
issue = 1
pages = 109 - 111
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doi = 10.1038/nsmb1326
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quote = ]

Tudor domains have also been found to be involved in RNA binding. The structural basis for ligand binding by tudor domains is not understood.

Other tudor domain containing proteins include AKAP1 (A-kinase anchor protein 1) [cite journal
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author = Rogne M, Landsverk HB, Van Eynde A, Beullens M, Bollen M, Collas P, Küntziger T
date =
year = 2006
month = Dec
title = The KH-Tudor Domain of A-Kinase Anchoring Protein 149 Mediates RNA-Dependent Self-Association
journal = Biochemistry
volume = 45
issue = 50
pages = 14980 -14989
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doi = 10.1021/bi061418y
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quote = ] and ARID4A (AT rich interactive domain 4A) among others.

References