RA33

RA33

RA33, also known as heterogeneous nuclear ribonucleoprotein A2/B1 is an autoantigen in human autoimmune diseases.

In 1989, a novel class of autoantibodies were detected in sera of patients with rheumatoid arthritis (RA) which were directed to a protein with an estimated molecular mass of approximately 33 kDa contained in nuclear extracts from HeLa cells [Hassfeld et al.: Demonstration of a new antinuclear antibody (anti-RA33) that is highly specific for rheumatoid arthritis. "Arthritis & Rheumatism 1989" ; 32:1515-20.] . The antigen was therefore given the name RA33. Protein sequencing of highly purified RA33 revealed that it was identical to the hetergoneous nuclear ribonucleoprotein A2 (hnRPA2B1) [Steiner et al.: Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistiguishable from the the A2 protein of the heterogeneous nuclear ribonucleoprotein complex. "Journal of Clinical Investigation 1992" ; 90:1061-66] . Nowadays, the name anti-RA33 defines autoantibodies that are directed to hnRNP-A2 and its splice variant hnRNP-B1. Anti-RA33 occur in approximately 30-35% of patients with RA, in 20-25% of patients with systemic lupus erythematosus and in 35-40% of patients with mixed connective tissue disease, being rare or absent in other arthritic conditions with a non-autoimmune etiology [Steiner et al.: Autoantibodies to the A/B proteins of the heterogeneous nuclear ribonucleoprotein complex: Novel tools for the diagnosis of rheumatic diseases. "International Archives of Allergology and Immunology 1996";111:314-19.] . Anti-RA33 can be easily detected by immunoblotting employing crude nuclear extracts or the recombinant antigen. Fo routine diagnostics also ELISA can be employed which is somewhat less sensitive than immunoblotting. The use of indirect immunofluorescence is of limited usefulness for detecting anti-RA33. The pathogenic role of anti-RA33 is not fully understood. Anti-RA33 and T cells directed against RA33, that can be found in about 60% of RA patients might contribute to autoimmune inflammation by immune complex formation or by virtue of secretion of cytokines that may initiate and drive the pathogenic process [Fritsch et al.: Characterization of autoreactive T cells to the autoantigens RA33 (hnRNP A2) and filaggrin in patients with rheumatoid arthritis. "Journal of Immunology 2002" 169:1068-76] . Of note, anti-RA33 are detectable already in the earliest disease stage of RA or even years before the onset of actual clinical disease. The positive predictive value of anti-RA33 is 74%. However, anti-RA33 are not associated with bone erosions or disease activity. In the absence of rheumatoid factor and anti-citrullinated protein antibody they are associated with a milder disease course of RA rather.

References


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • Lewis Charles Levin — (November 10, 1808 March 14, 1860) was the first Jewish person elected to the United States Congress. Lewis Charles Levin was born in Charleston, South Carolina and graduated from the University of South Carolina in 1828. After teaching for a… …   Wikipedia

  • List of St. Anthony Hall members — Founders of Alpha Chapter of St. Anthony Hall (Columbia College + N.Y.U.), January 17, 1847= According to the 20th edition (1991) of Baird s Manual of American College Fraternities ISBN 0 9637159 0 9, two founding members are cited: * Edward… …   Wikipedia

  • 23999 Rinner — Infobox Planet minorplanet = yes width = 25em bgcolour = #FFFFC0 apsis = name = Rinner symbol = caption = discovery = yes discovery ref = discoverer = L. Bernasconi discovery site = St. Michel sur Meurthe discovered = September 9, 1999… …   Wikipedia

  • List of Trojan asteroids (Greek camp) — This is a list of Jupiter s Trojan asteroids that lie in the elongated, curved regions around the leading L4 Lagrangian point 60° ahead of Jupiter in the same orbit.All the asteroids at the leading L4 point have names corresponding to… …   Wikipedia

  • HNRPA2B1 — Heterogeneous nuclear ribonucleoprotein A2/B1, also known as HNRPA2B1, is a human gene. PBB Summary section title = summary text = This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) …   Wikipedia

  • Liste des asteroides (20001-21000) — Liste des astéroïdes (20001 21000) Voici la liste des astéroïdes numérotés de 20001 à 21000. Les astéroïdes sont numérotés lorsque leur orbite est confirmée, ce qui peut parfois se produire longtemps après leur découverte. Ils sont classés ici… …   Wikipédia en Français

  • Liste des asteroides (23001-24000) — Liste des astéroïdes (23001 24000) Voici la liste des astéroïdes numérotés de 23001 à 24000. Les astéroïdes sont numérotés lorsque leur orbite est confirmée, ce qui peut parfois se produire longtemps après leur découverte. Ils sont classés ici… …   Wikipédia en Français

  • Liste des asteroides (83001-84000) — Liste des astéroïdes (83001 84000) Voici la liste des astéroïdes numérotés de 83001 à 84000. Les astéroïdes sont numérotés lorsque leur orbite est confirmée, ce qui peut parfois se produire longtemps après leur découverte. Ils sont classés ici… …   Wikipédia en Français

  • Liste des asteroides (92001-93000) — Liste des astéroïdes (92001 93000) Voici la liste des astéroïdes numérotés de 92001 à 93000. Les astéroïdes sont numérotés lorsque leur orbite est confirmée, ce qui peut parfois se produire longtemps après leur découverte. Ils sont classés ici… …   Wikipédia en Français

  • Liste des astéroïdes (20001-21000) — Voici la liste des astéroïdes numérotés de 20001 à 21000. Les astéroïdes sont numérotés lorsque leur orbite est confirmée, ce qui peut parfois se produire longtemps après leur découverte. Ils sont classés ici par leur numéro et donc… …   Wikipédia en Français

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”