HNRPA2B1

Heterogeneous nuclear ribonucleoprotein A2/B1, also known as HNRPA2B1, is a human gene.

PBB_Summary
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summary_text = This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.cite web | title = Entrez Gene: HNRPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3181| accessdate = ] HnRNPA2B1 is an autoantigen in autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and mixed connective tissue disease. When referred to as an autoantigen, hnRNPA2B1 is also known as RA33.

References

Further reading

PBB_Further_reading
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*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Bauw G, Rasmussen HH, van den Bulcke M, "et al." |title=Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes. |journal=Electrophoresis |volume=11 |issue= 7 |pages= 528–36 |year= 1990 |pmid= 1699755 |doi= 10.1002/elps.1150110703
*cite journal | author=Wilk HE, Schaefer KP, Agris PF, "et al." |title=U1 SnRNP association with HnRNP involves an initial non-specific splice-site independent interaction of U1 SnRNP protein with HnRNA. |journal=Mol. Cell. Biochem. |volume=106 |issue= 1 |pages= 55–66 |year= 1991 |pmid= 1833625 |doi=
*cite journal | author=Burd CG, Swanson MS, Görlach M, Dreyfuss G |title=Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 24 |pages= 9788–92 |year= 1990 |pmid= 2557628 |doi=
*cite journal | author=Kumar A, Williams KR, Szer W |title=Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins. |journal=J. Biol. Chem. |volume=261 |issue= 24 |pages= 11266–73 |year= 1986 |pmid= 3733753 |doi=
*cite journal | author=Faura M, Renau-Piqueras J, Bachs O, Bosser R |title=Differential distribution of heterogeneous nuclear ribonucleoproteins in rat tissues. |journal=Biochem. Biophys. Res. Commun. |volume=217 |issue= 2 |pages= 554–60 |year= 1996 |pmid= 7503735 |doi=
*cite journal | author=Kozu T, Henrich B, Schäfer KP |title=Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1. |journal=Genomics |volume=25 |issue= 2 |pages= 365–71 |year= 1995 |pmid= 7789969 |doi=
*cite journal | author=Biamonti G, Ruggiu M, Saccone S, "et al." |title=Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1. |journal=Nucleic Acids Res. |volume=22 |issue= 11 |pages= 1996–2002 |year= 1994 |pmid= 8029005 |doi=
*cite journal | author=Van Laer L, Van Camp G, Green ED, "et al." |title=Physical mapping of the HOXA1 gene and the hnRPA2B1 gene in a YAC contig from human chromosome 7p14-p15. |journal=Hum. Genet. |volume=99 |issue= 6 |pages= 831–3 |year= 1997 |pmid= 9187682 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700
*cite journal | author=Montuenga LM, Zhou J, Avis I, "et al." |title=Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development. |journal=Am. J. Respir. Cell Mol. Biol. |volume=19 |issue= 4 |pages= 554–62 |year= 1998 |pmid= 9761751 |doi=
*cite journal | author=Pancetti F, Bosser R, Krehan A, "et al." |title=Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 1 |pages= 17–22 |year= 1999 |pmid= 10381337 |doi= 10.1006/bbrc.1999.0849
*cite journal | author=Hamilton BJ, Nichols RC, Tsukamoto H, "et al." |title=hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 3 |pages= 646–51 |year= 1999 |pmid= 10441480 |doi= 10.1006/bbrc.1999.1040
*cite journal | author=Nichols RC, Wang XW, Tang J, "et al." |title=The RGG domain in hnRNP A2 affects subcellular localization. |journal=Exp. Cell Res. |volume=256 |issue= 2 |pages= 522–32 |year= 2000 |pmid= 10772824 |doi= 10.1006/excr.2000.4827
*cite journal | author=Matsui M, Horiguchi H, Kamma H, "et al." |title=Testis- and developmental stage-specific expression of hnRNP A2/B1 splicing isoforms, B0a/b. |journal=Biochim. Biophys. Acta |volume=1493 |issue= 1-2 |pages= 33–40 |year= 2000 |pmid= 10978504 |doi=
*cite journal | author=Zhou J, Allred DC, Avis I, "et al." |title=Differential expression of the early lung cancer detection marker, heterogeneous nuclear ribonucleoprotein-A2/B1 (hnRNP-A2/B1) in normal breast and neoplastic breast cancer. |journal=Breast Cancer Res. Treat. |volume=66 |issue= 3 |pages= 217–24 |year= 2001 |pmid= 11510693 |doi=
*cite journal | author=Pioli PA, Rigby WF |title=The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression. |journal=J. Biol. Chem. |volume=276 |issue= 43 |pages= 40346–52 |year= 2001 |pmid= 11517223 |doi= 10.1074/jbc.M105391200
*cite journal | author=Kim SH, Dierssen M, Ferreres JC, "et al." |title=Increased protein levels of heterogeneous nuclear ribonucleoprotein A2/B1 in fetal Down syndrome brains. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 273–80 |year= 2002 |pmid= 11771750 |doi=
*cite journal | author=Andersen JS, Lyon CE, Fox AH, "et al." |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=

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