ABCG2

ATP-binding cassette, sub-family G (WHITE), member 2
Identifiers
Symbols	ABCG2; ABC15; ABCP; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; MGC102821; MRX; MXR; MXR1
External IDs	OMIM: 603756 MGI: 1347061 HomoloGene: 55852 GeneCards: ABCG2 Gene
Gene Ontology Molecular function • nucleotide binding • transporter activity • protein binding • ATP binding • xenobiotic-transporting ATPase activity • heme transporter activity • ATPase activity • ATPase activity, coupled to transmembrane movement of substances • protein homodimerization activity Cellular component • plasma membrane • integral to membrane Biological process • transport • cellular iron ion homeostasis • heme transport • response to drug • urate metabolic process • transmembrane transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9429	26357
Ensembl	ENSG00000118777	ENSMUSG00000029802
UniProt	Q9UNQ0	Q7TMS5
RefSeq (mRNA)	NM_004827.2	NM_011920.3
RefSeq (protein)	NP_004818.2	NP_036050.1
Location (UCSC)	Chr 4: 89.01 – 89.15 Mb	Chr 6: 58.53 – 58.64 Mb
PubMed search	[1]	[2]

ATP-binding cassette sub-family G member 2 is a protein that in humans is encoded by the ABCG2 gene.^[1][2] ABCG2 has also been designated as CDw338 (cluster of differentiation w338).

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as the Breast Cancer Resistance Protein, this protein functions as a xenobiotic transporter which may play a role in multi-drug resistance to chemotherapeutic agents including mitoxantrone and camptothecin analogues. Early observations of significant ABCG2-mediated resistance to anthracyclines were subsequently attributed mutations encountered in vitro but not in nature or the clinic. Significant expression of this protein has been observed in the placenta,^[3] and it has been shown to have a role in protecting the fetus from xenobiotics in the maternal circulation.^[4] The transporter has also been shown to play protective roles in blocking absorption at the apical membrane of the intestine, and at the blood-testis barrier,^[4] the blood-brain barrier,^[4] and the membranes of hematopoietic progenitor and other stem cells. At the apical membranes of the liver and kidney, it enhances excretion of xenobiotics. In the lactating mammary gland, it has a role in excreting vitamins such as riboflavin and biotin into milk.^[4]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles. ^[5]

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Fluorouracil (5-FU) Activity edit

See also

• ATP-binding cassette transporter

References

1. ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702. 
2. ^ Doyle LA, Yang W, Abruzzo LV, Krogmann T, Gao Y, Rishi AK, Ross DD (Jan 1999). "A multidrug resistance transporter from human MCF-7 breast cancer cells". Proc Natl Acad Sci U S A 95 (26): 15665–70. doi:10.1073/pnas.95.26.15665. PMC 28101. PMID 9861027. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=28101. 
3. ^ "Entrez Gene: ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9429. 
4. ^ ^{a b c d} Vlaming, M. L. H.; Lagas, J. S.; Schinkel, A. H. (2008-12-07). "Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice". Advanced Drug Delivery Reviews (Elsevier) 61 (1): 14–25. doi:10.1016/j.addr.2008.08.007. PMID 19118589. 
5. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". http://www.wikipathways.org/index.php/Pathway:WP1601. 

Further reading

• Hazai E, Bikadi Z. (2008). "Homology modeling of breast cancer resistance protein (ABCG2).". J Struct Biol. 162 (1): 63–74. doi:10.1016/j.jsb.2007.12.001. PMID 18249138. 
• Abbott BL (2006). "ABCG2 (BCRP): a cytoprotectant in normal and malignant stem cells". Clin Adv Hematol Oncol. 4 (1): 63–72. PMID 16562373. 
• Schmitz G, Langmann T, Heimerl S (2002). "Role of ABCG1 and other ABCG family members in lipid metabolism.". J. Lipid Res. 42 (10): 1513–20. PMID 11590207. 
• Ejendal KF, Hrycyna CA (2003). "Multidrug resistance and cancer: the role of the human ABC transporter ABCG2.". Curr. Protein Pept. Sci. 3 (5): 503–11. doi:10.2174/1389203023380521. PMID 12369998. 
• Doyle LA, Ross DD (2003). "Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2).". Oncogene 22 (47): 7340–58. doi:10.1038/sj.onc.1206938. PMID 14576842. 
• Sugimoto Y, Tsukahara S, Ishikawa E, Mitsuhashi J (2005). "Breast cancer resistance protein: molecular target for anticancer drug resistance and pharmacokinetics/pharmacodynamics.". Cancer Sci. 96 (8): 457–65. doi:10.1111/j.1349-7006.2005.00081.x. PMID 16108826. 
• Ishikawa T, Tamura A, Saito H, et al. (2006). "Pharmacogenomics of the human ABC transporter ABCG2: from functional evaluation to drug molecular design.". Naturwissenschaften 92 (10): 451–63. doi:10.1007/s00114-005-0019-4. PMID 16160819. 
• Krishnamurthy P, Schuetz JD (2006). "Role of ABCG2/BCRP in biology and medicine.". Annu. Rev. Pharmacol. Toxicol. 46: 381–410. doi:10.1146/annurev.pharmtox.46.120604.141238. PMID 16402910. 
• Robey RW, Polgar O, Deeken J, et al. (2007). "ABCG2: determining its relevance in clinical drug resistance.". Cancer Metastasis Rev. 26 (1): 39–57. doi:10.1007/s10555-007-9042-6. PMID 17323127. 

External links

• MeSH ABCG2+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Clusters of differentiation ABC transporters Membrane protein stubs Wikimedia Foundation. 2010. Игры ⚽ Поможем написать курсовую Kalerab Gigant Ursoiu River (Groşeni) Look at other dictionaries: Abcg2 — is a member of the ATP Binding Cassette Transporter family of transmembrane, substrate effluxing proteins. Other names for ABGC2 have included BCRP (Breast Cancer Resistance Protein) and MXR (Mitoxantrone Resistance Protein).References*… …   Wikipedia Catechin — IUPAC name (2R,3S) 2 (3,4 dihydroxyphenyl) 3,4 dihydro 2H chromene 3,5,7 …   Wikipedia Stratégies pour franchir la barrière hémato-encéphalique — Traduction à relire …   Wikipédia en Français Gout — Podagra redirects here. For the moth genus, see Podagra (moth). Gout Classification and external resources Gout, a 1799 caricature by James Gillray …   Wikipedia ATP-binding cassette transporter — ATP binding cassette transporters (ABC transporter) are members of a superfamily that is one of the largest, and most ancient families with representatives in all extant phyla from prokaryotes to humans. Ref|Jones2004. These are transmembrane… …   Wikipedia MRX — may refer to:*The ABCG2 gene *MRX DNA damage repair complex in yeast *Medicis Pharmaceutical Corp., stock symbol …   Wikipedia ABCP — can have the following meanings: * ABCP is an alternate name for ABCG2, the human gene ATP binding cassette, sub family G (WHITE), member 2. * ABCP is an acronym for Asset Backed Commercial Paper …   Wikipedia ATP-binding domain of ABC transporters — Pfam box Symbol = ABC tran Name = width = caption =Multidrug ABC transporter SAV1866, closed state Pfam= PF00005 InterPro= IPR003439 SMART= PROSITE = PDOC00185 SCOP = 1b0u TCDB = 3.A.1 OPM family= 17 OPM protein=2hyd PDB=PDB3|1vplA:29 210… …   Wikipedia ABCG8 — ATP binding cassette, sub family G (WHITE), member 8 (sterolin 2), also known as ABCG8, is a human gene.cite web | title = Entrez Gene: ABCG8 ATP binding cassette, sub family G (WHITE), member 8 (sterolin 2)| url =… …   Wikipedia ABCA7 — ATP binding cassette, sub family A (ABC1), member 7, also known as ABCA7, is a human gene.cite web | title = Entrez Gene: ABCA7 ATP binding cassette, sub family A (ABC1), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”