Interleukin 8 receptor, beta

Interleukin 8 receptor, beta
Chemokine (C-X-C motif) receptor 2
Identifiers
Symbols CXCR2; CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
External IDs OMIM146928 MGI105303 HomoloGene10439 IUPHAR: GeneCards: CXCR2 Gene
RNA expression pattern
PBB GE IL8RB 207008 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3579 12765
Ensembl ENSG00000180871 ENSMUSG00000026180
UniProt P25025 Q53X27
RefSeq (mRNA) NM_001168298.1 NM_009909.3
RefSeq (protein) NP_001161770.1 NP_034039.1
Location (UCSC) Chr 2:
218.99 – 219 Mb
Chr 1:
74.2 – 74.21 Mb
PubMed search [1] [2]

Interleukin 8 receptor, beta is a chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.[1]

Contents

Function

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands CXCL2, CXCL3, and CXCL5.

This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.[2]

Senescence

Knock down studies involving the chemokine receptor CXCR2 alleviates both replicative and oncogene-induced senescence (OIS) and diminishes the DNA-damage response. Alternatively, ectopic expression of CXCR2 results in premature senescence via a p53-dependent mechanism.[3]

See also

References

  1. ^ Morris SW, Nelson N, Valentine MB, Shapiro DN, Look AT, Kozlosky CJ, Beckmann MP, Cerretti DP (November 1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35". Genomics 14 (3): 685–91. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896. 
  2. ^ "Entrez Gene: IL8RB interleukin 8 receptor, beta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3579. 
  3. ^ Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J. (June 2008). "Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence.". Cell. 133 (6): 1006–18. doi:10.1016/j.cell.2008.03.038. PMID 18555777. 

External links

Further reading

  • Brandt E, Ludwig A, Petersen F, Flad HD (2001). "Platelet-derived CXC chemokines: old players in new games.". Immunol. Rev. 177: 204–16. doi:10.1034/j.1600-065X.2000.17705.x. PMID 11138777. 
  • Robertson MJ (2002). "Role of chemokines in the biology of natural killer cells.". J. Leukoc. Biol. 71 (2): 173–83. PMID 11818437. 
  • Ahuja SK, Ozçelik T, Milatovitch A, et al. (1993). "Molecular evolution of the human interleukin-8 receptor gene cluster.". Nat. Genet. 2 (1): 31–6. doi:10.1038/ng0992-31. PMID 1303245. 
  • Lee J, Horuk R, Rice GC, et al. (1992). "Characterization of two high affinity human interleukin-8 receptors.". J. Biol. Chem. 267 (23): 16283–7. PMID 1379593. 
  • Morris SW, Nelson N, Valentine MB, et al. (1992). "Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35.". Genomics 14 (3): 685–91. doi:10.1016/S0888-7543(05)80169-7. PMID 1427896. 
  • Holmes WE, Lee J, Kuang WJ, et al. (1991). "Structure and functional expression of a human interleukin-8 receptor.". Science 253 (5025): 1278–80. doi:10.1126/science.1840701. PMID 1840701. 
  • Murphy PM, Tiffany HL (1991). "Cloning of complementary DNA encoding a functional human interleukin-8 receptor.". Science 253 (5025): 1280–3. doi:10.1126/science.1891716. PMID 1891716. 
  • Sprenger H, Lloyd AR, Lautens LL, et al. (1994). "Structure, genomic organization, and expression of the human interleukin-8 receptor B gene.". J. Biol. Chem. 269 (15): 11065–72. PMID 7512557. 
  • Morohashi H, Miyawaki T, Nomura H, et al. (1995). "Expression of both types of human interleukin-8 receptors on mature neutrophils, monocytes, and natural killer cells.". J. Leukoc. Biol. 57 (1): 180–7. PMID 7829970. 
  • Ahuja SK, Shetty A, Tiffany HL, Murphy PM (1994). "Comparison of the genomic organization and promoter function for human interleukin-8 receptors A and B.". J. Biol. Chem. 269 (42): 26381–9. PMID 7929358. 
  • Cacalano G, Lee J, Kikly K, et al. (1994). "Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog.". Science 265 (5172): 682–4. doi:10.1126/science.8036519. PMID 8036519. 
  • Harada A, Kuno K, Nomura H, et al. (1994). "Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor.". Gene 142 (2): 297–300. doi:10.1016/0378-1119(94)90278-X. PMID 8194768. 
  • Schnitzel W, Monschein U, Besemer J (1994). "Monomer-dimer equilibria of interleukin-8 and neutrophil-activating peptide 2. Evidence for IL-8 binding as a dimer and oligomer to IL-8 receptor B.". J. Leukoc. Biol. 55 (6): 763–70. PMID 8195702. 
  • Mueller SG, Schraw WP, Richmond A (1994). "Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells.". J. Biol. Chem. 269 (3): 1973–80. PMID 8294449. 
  • Wu D, LaRosa GJ, Simon MI (1993). "G protein-coupled signal transduction pathways for interleukin-8.". Science 261 (5117): 101–3. doi:10.1126/science.8316840. PMID 8316840. 
  • Cerretti DP, Kozlosky CJ, Vanden Bos T, et al. (1993). "Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2.". Mol. Immunol. 30 (4): 359–67. doi:10.1016/0161-5890(93)90065-J. PMID 8384312. 
  • Ahuja SK, Lee JC, Murphy PM (1996). "CXC chemokines bind to unique sets of selectivity determinants that can function independently and are broadly distributed on multiple domains of human interleukin-8 receptor B. Determinants of high affinity binding and receptor activation are distinct.". J. Biol. Chem. 271 (1): 225–32. doi:10.1074/jbc.271.1.225. PMID 8550564. 
  • Hammond ME, Shyamala V, Siani MA, et al. (1996). "Receptor recognition and specificity of interleukin-8 is determined by residues that cluster near a surface-accessible hydrophobic pocket.". J. Biol. Chem. 271 (14): 8228–35. doi:10.1074/jbc.271.14.8228. PMID 8626516. 
  • Damaj BB, McColl SR, Mahana W, et al. (1996). "Physical association of Gi2alpha with interleukin-8 receptors.". J. Biol. Chem. 271 (22): 12783–9. doi:10.1074/jbc.271.22.12783. PMID 8662698. 
  • Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor.". J. Biol. Chem. 271 (34): 20545–50. doi:10.1074/jbc.271.34.20545. PMID 8702798. 

External links



Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Interleukin 12 receptor, beta 2 subunit — is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene.cite web | title = Entrez Gene: IL12RB2 interleukin 12 receptor, beta 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3595|… …   Wikipedia

  • Interleukin 12 receptor, beta 1 subunit — Interleukin 12 receptor, beta 1 is a subunit of the interleukin 12 receptor. IL12RB1, is its human gene.cite web | title = Entrez Gene: IL12RB1 interleukin 12 receptor, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Interleukin 10 receptor, beta subunit — is a subunit for the interleukin 10 receptor. IL10RB is its human gene.cite web | title = Entrez Gene: IL10RB interleukin 10 receptor, beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=3588| accessdate …   Wikipedia

  • Interleukin 20 receptor, beta subunit — Interleukin 20 receptor beta, also known as IL20RB, is a human gene.cite web | title = Entrez Gene: IL20RB interleukin 20 receptor beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=53833| accessdate = ]… …   Wikipedia

  • Interleukin-12 subunit beta — Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) PDB rendering based on 1f42 …   Wikipedia

  • Interleukin 20 receptor, alpha subunit — is a subunit for the interleukin 20 receptor. IL20RA is its human gene.cite web | title = Entrez Gene: IL20RA interleukin 20 receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=53832| accessdate …   Wikipedia

  • Interleukin 8 receptor, alpha — Chemokine (C X C motif) receptor 1 Rendering of 1ILP …   Wikipedia

  • Interleukin-12 receptor — protein Name = interleukin 12 receptor, beta 1 caption = width = HGNCid = 5971 Symbol = IL12RB1 AltSymbols = IL12RB, CD212 EntrezGene = 3594 OMIM = 601604 RefSeq = NM 005535 UniProt = P42701 PDB = ECnumber = Chromosome = 19 Arm = p Band = 13.1… …   Wikipedia

  • Interleukin-15 receptor — protein Name = interleukin 15 receptor, alpha caption = width = HGNCid = 5978 Symbol = IL15RA AltSymbols = EntrezGene = 3601 OMIM = 601070 RefSeq = NM 172200 UniProt = Q13261 PDB = ECnumber = Chromosome = 10 Arm = p Band = 15… …   Wikipedia

  • Interleukin-8 receptor — protein Name = interleukin 8 receptor, alpha caption = width = HGNCid = 6026 Symbol = IL8RA AltSymbols = CMKAR1, CXCR1, CKR 1, CDw128a, CD181 EntrezGene = 3577 OMIM = 146929 RefSeq = NM 000634 UniProt = P25024 PDB = ECnumber = Chromosome = 2 Arm …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”