TNFRSF21

Tumor necrosis factor receptor superfamily, member 21, also known as TNFRSF21, is a human gene.cite web | title = Entrez Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27242| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors. Knockout studies in mice suggested that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation.cite web | title = Entrez Gene: TNFRSF21 tumor necrosis factor receptor superfamily, member 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27242| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pan G, Bauer JH, Haridas V, "et al." |title=Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. |journal=FEBS Lett. |volume=431 |issue= 3 |pages= 351–6 |year= 1998 |pmid= 9714541 |doi=
*cite journal | author=Liu J, Na S, Glasebrook A, "et al." |title=Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. |journal=Immunity |volume=15 |issue= 1 |pages= 23–34 |year= 2001 |pmid= 11485735 |doi=
*cite journal | author=Zhao H, Yan M, Wang H, "et al." |title=Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice. |journal=J. Exp. Med. |volume=194 |issue= 10 |pages= 1441–8 |year= 2001 |pmid= 11714751 |doi=
*cite journal | author=Kasof GM, Lu JJ, Liu D, "et al." |title=Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB. |journal=Oncogene |volume=20 |issue= 55 |pages= 7965–75 |year= 2002 |pmid= 11753679 |doi= 10.1038/sj.onc.1204985
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Mai T, Wang X, Zhang Z, "et al." |title=Androgen receptor coregulator ARA267-alpha interacts with death receptor-6 revealed by the yeast two-hybrid. |journal=Sci. China, C, Life Sci. |volume=47 |issue= 5 |pages= 442–8 |year= 2005 |pmid= 15623156 |doi=

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