LRP1

LRP1

Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), also known as LRP1 or CD91, is a protein forming a receptor found in the plasma membrane of human cells involved in receptor-mediated endocytosis.

LRP1 and Alzheimer's disease

Neurons require cholesterol to function. Cholesterol is imported into the neuron by the apolipoprotein apoE4 via LRP1 receptors on the cell surface. It thought that a causal factor in Alzheimer's is the malfunction of this process which damages neurons by starving them of cholesterol. [Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56(1):66-78. PMID 17920016]

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References

ee also

* Cluster of differentiation
* Low density lipoprotein receptor gene family

Further reading

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*cite journal | author=Li Z, Dai J, Zheng H, "et al." |title=An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response. |journal=Front. Biosci. |volume=7 |issue= |pages= d731–51 |year= 2002 |pmid= 11861214 |doi=
*cite journal | author=van der Geer P |title=Phosphorylation of LRP1: regulation of transport and signal transduction. |journal=Trends Cardiovasc. Med. |volume=12 |issue= 4 |pages= 160–5 |year= 2002 |pmid= 12069755 |doi=
*cite journal | author=May P, Herz J |title=LDL receptor-related proteins in neurodevelopment. |journal=Traffic |volume=4 |issue= 5 |pages= 291–301 |year= 2004 |pmid= 12713657 |doi=
*cite journal | author=Llorente-Cortés V, Badimon L |title=LDL receptor-related protein and the vascular wall: implications for atherothrombosis. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=25 |issue= 3 |pages= 497–504 |year= 2005 |pmid= 15705932 |doi= 10.1161/01.ATV.0000154280.62072.fd
*cite journal | author=Huang SS, Huang JS |title=TGF-beta control of cell proliferation. |journal=J. Cell. Biochem. |volume=96 |issue= 3 |pages= 447–62 |year= 2005 |pmid= 16088940 |doi= 10.1002/jcb.20558
*cite journal | author=Lillis AP, Mikhailenko I, Strickland DK |title=Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability. |journal=J. Thromb. Haemost. |volume=3 |issue= 8 |pages= 1884–93 |year= 2005 |pmid= 16102056 |doi= 10.1111/j.1538-7836.2005.01371.x

External links

*

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