ITGB4

Integrin, beta 4 (ITGB4) also known as CD104 (Cluster of Differentiation 104), is a human gene.cite web | title = Entrez Gene: ITGB4 integrin, beta 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3691| accessdate = ]

PBB_Summary
section_title =
summary_text = Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: ITGB4 integrin, beta 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3691| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lipscomb EA, Mercurio AM |title=Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. |journal=Cancer Metastasis Rev. |volume=24 |issue= 3 |pages= 413–23 |year= 2006 |pmid= 16258729 |doi= 10.1007/s10555-005-5133-4
*cite journal | author=Sonnenberg A, Linders CJ, Modderman PW, "et al." |title=Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8. |journal=J. Cell Biol. |volume=110 |issue= 6 |pages= 2145–55 |year= 1990 |pmid= 1693624 |doi=
*cite journal | author=Tamura RN, Rozzo C, Starr L, "et al." |title=Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4. |journal=J. Cell Biol. |volume=111 |issue= 4 |pages= 1593–604 |year= 1990 |pmid= 1976638 |doi=
*cite journal | author=Hogervorst F, Kuikman I, van Kessel AG, Sonnenberg A |title=Molecular cloning of the human alpha 6 integrin subunit. Alternative splicing of alpha 6 mRNA and chromosomal localization of the alpha 6 and beta 4 genes. |journal=Eur. J. Biochem. |volume=199 |issue= 2 |pages= 425–33 |year= 1991 |pmid= 2070796 |doi=
*cite journal | author=Vogel BE, Tarone G, Giancotti FG, "et al." |title=A novel fibronectin receptor with an unexpected subunit composition (alpha v beta 1). |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 5934–7 |year= 1990 |pmid= 2138612 |doi=
*cite journal | author=Suzuki S, Naitoh Y |title=Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. |journal=EMBO J. |volume=9 |issue= 3 |pages= 757–63 |year= 1990 |pmid= 2311577 |doi=
*cite journal | author=Hogervorst F, Kuikman I, von dem Borne AE, Sonnenberg A |title=Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. |journal=EMBO J. |volume=9 |issue= 3 |pages= 765–70 |year= 1990 |pmid= 2311578 |doi=
*cite journal | author=Kajiji S, Tamura RN, Quaranta V |title=A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. |journal=EMBO J. |volume=8 |issue= 3 |pages= 673–80 |year= 1989 |pmid= 2542022 |doi=
*cite journal | author=Hemler ME, Crouse C, Sonnenberg A |title=Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines. |journal=J. Biol. Chem. |volume=264 |issue= 11 |pages= 6529–35 |year= 1989 |pmid= 2649503 |doi=
*cite journal | author=Vidal F, Aberdam D, Miquel C, "et al." |title=Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. |journal=Nat. Genet. |volume=10 |issue= 2 |pages= 229–34 |year= 1995 |pmid= 7545057 |doi= 10.1038/ng0695-229
*cite journal | author=Mainiero F, Pepe A, Wary KK, "et al." |title=Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. |journal=EMBO J. |volume=14 |issue= 18 |pages= 4470–81 |year= 1995 |pmid= 7556090 |doi=
*cite journal | author=Clarke AS, Lotz MM, Mercurio AM |title=A novel structural variant of the human beta 4 integrin cDNA. |journal=Cell Adhes. Commun. |volume=2 |issue= 1 |pages= 1–6 |year= 1995 |pmid= 7982032 |doi=
*cite journal | author=Weeks BS, Desai K, Loewenstein PM, "et al." |title=Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein. |journal=J. Biol. Chem. |volume=268 |issue= 7 |pages= 5279–84 |year= 1993 |pmid= 8444901 |doi=
*cite journal | author=Iacovacci S, Gagnoux-Palacios L, Zambruno G, "et al." |title=Genomic organization of the human integrin beta4 gene. |journal=Mamm. Genome |volume=8 |issue= 6 |pages= 448–50 |year= 1997 |pmid= 9166594 |doi=
*cite journal | author=Mainiero F, Murgia C, Wary KK, "et al." |title=The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. |journal=EMBO J. |volume=16 |issue= 9 |pages= 2365–75 |year= 1997 |pmid= 9171350 |doi= 10.1093/emboj/16.9.2365
*cite journal | author=Pulkkinen L, Kurtz K, Xu Y, "et al." |title=Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia. |journal=Lab. Invest. |volume=76 |issue= 6 |pages= 823–33 |year= 1997 |pmid= 9194858 |doi=
*cite journal | author=van Leusden MR, Kuikman I, Sonnenberg A |title=The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 826–30 |year= 1997 |pmid= 9207246 |doi= 10.1006/bbrc.1997.6892
*cite journal | author=von Bredow DC, Nagle RB, Bowden GT, Cress AE |title=Cleavage of beta 4 integrin by matrilysin. |journal=Exp. Cell Res. |volume=236 |issue= 1 |pages= 341–5 |year= 1997 |pmid= 9344615 |doi= 10.1006/excr.1997.3711
*cite journal | author=Biffo S, Sanvito F, Costa S, "et al." |title=Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 30314–21 |year= 1997 |pmid= 9374518 |doi=
*cite journal | author=Pulkkinen L, Kim DU, Uitto J |title=Epidermolysis bullosa with pyloric atresia: novel mutations in the beta4 integrin gene (ITGB4). |journal=Am. J. Pathol. |volume=152 |issue= 1 |pages= 157–66 |year= 1998 |pmid= 9422533 |doi=

External links

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