Triheptanoin

chembox new
ImageFile=Triheptanoin.pngImageSize=250px
IUPACName=1,3-Di(heptanoyloxy)propan-2-yl heptanoate
OtherNames=
Section1=Chembox Identifiers
CASNo=620-67-7
PubChem=69286
SMILES=CCCCCCC(=O)OCC(COC(=O)CCCCCC)OC(=O)CCCCCC
Section2=Chembox Properties
Formula=C₂₄H₄₄O₆
MolarMass=428.60 g/mol
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3=Chembox Hazards
MainHazards=
FlashPt=
Autoignition=

Triheptanoin is triglyceride that is composed of three seven-carbon fatty acids. These odd-carbon fatty acids are able to provide anaplerotic substrates for the the TCA cycle. Triheptanoin is used clinically in humans to treat inherited metabolic diseases, such as Pyruvate carboxylase deficiency. It also appears to increase the efficacy of the ketogenic diet as a treatment for epilepsy.

Since triheptanoin is composed of odd-carbon fatty acids, it can produce ketone bodies with five carbon atoms, as opposed to even-carbon fatty acids which are metabolized to ketone bodies with four carbon atoms. The five-carbon ketones produced from triheptanoin are Beta-ketopentanoate and Beta-hydroxypentanoate. Each of these ketone bodies easily crosses the blood–brain barrier and enters the brain.

References

*

*cite journal |author=Mochel F, DeLonlay P, Touati G, "et al" |title=Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy |journal=Mol. Genet. Metab. |volume=84 |issue=4 |pages=305–12 |year=2005 |month=April |pmid=15781190 |doi=10.1016/j.ymgme.2004.09.007 |url=

External links

* [http://pepck-and-the-ketogenic-diet.com/cataplerosis.html Cataplerosis and anaplerosis]
* [http://pepck-and-the-ketogenic-diet.com/Triheptanoin-odd-carbon-fats.html triheptanoin oil and odd-carbon fatty acids]