3-Oxopentanoic acid

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ImageFile=3-oxopentanoic acid.pngImageSize=200px
IUPACName=3-Oxopentanoic acid
OtherNames=beta-Ketopentanoate
3-Oxopentanoate
3-Oxovaleric acid
3-Ketovaleric acid
Section1=Chembox Identifiers
CASNo=10191-25-0
PubChem=439684
SMILES=CCC(=O)CC(=O)O
Section2=Chembox Properties
Formula=C₅H₈O₃
MolarMass=116.12 g/mol
Appearance=
Density=
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Section3=Chembox Hazards
MainHazards=
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3-Oxopentanoic acid, or beta-ketopentanoate, is a 5-carbon ketone body. It is made from odd carbon fatty acids in the liver and rapidly enters the brain. As opposed to 4-carbon ketone bodies, beta-ketopentanoate is anaplerotic, meaning it can refill the pool of TCA cycle intermediates. The triglyceride triheptanoin is used clinically to produce beta-ketopentanoate. [cite journal| title=Parenteral and Enteral Metabolism of AnapleroticTriheptanoin in Normal Rats| author=Renée P. Kinman, Takhar Kasumov, Kathryn A. Jobbins, Katherine R. Thomas,Jillian Adams, Lisa N. Brunengraber, Gerd Kutz, Wolf-Ulrich Brewer, Charles R. Roe, and Henri Brunengraber| journal=Am J Physiol Endocrinol Metab| pages=E860-E866| volume=291| doi=10.1152/ajpendo.00366.2005| year=2006 [http://ajpendo.physiology.org/cgi/reprint/00366.2005v1.pdf Reprint] ]

References

External links

* [http://pepck-and-the-ketogenic-diet.com/cataplerosis.html Cataplerosis and anaplerosis]
* [http://pepck-and-the-ketogenic-diet.com/Triheptanoin-odd-carbon-fats.html triheptanoin oil and odd-carbon fatty acids]