3-Hydroxypentanoic acid

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ImageFile=3-hydroxypentanoic acid.pngImageSize=200px
IUPACName=3-Hydroxypentanoic acid
OtherNames=3-Hydroxyvalerate
3-Hydroxy valeric acid
beta-Hydroxyvaleric acid
beta-Hydroxypentanoate
Section1=Chembox Identifiers
CASNo=10237-77-1
PubChem=107802
SMILES=CCC(CC(=O)O)O
Section2=Chembox Properties
Formula=C₅H₁₀O₃
MolarMass=118.13 g/mol
Appearance=
Density=
MeltingPt=
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Section3=Chembox Hazards
MainHazards=
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3-Hydroxypentanoic acid, or beta-hydroxypentanoate is a 5-carbon ketone body. It is made from odd carbon fatty acids in the liver and rapidly enters the brain. As opposed to 4-carbon ketone bodies, 3-hydroxypentanoic acid is anaplerotic, meaning it can refill the pool of TCA cycle intermediates. The triglyceride triheptanoin is used clinically to produce beta-hydroxypentanoate. [cite journal| title=Parenteral and Enteral Metabolism of AnapleroticTriheptanoin in Normal Rats| author=Renée P. Kinman, Takhar Kasumov, Kathryn A. Jobbins, Katherine R. Thomas,Jillian Adams, Lisa N. Brunengraber, Gerd Kutz, Wolf-Ulrich Brewer, Charles R. Roe, and Henri Brunengraber| journal=Am J Physiol Endocrinol Metab| pages=E860-E866| volume=291| doi=10.1152/ajpendo.00366.2005| year=2006 [http://ajpendo.physiology.org/cgi/reprint/00366.2005v1.pdf Reprint] ]

References

External links

* [http://pepck-and-the-ketogenic-diet.com/cataplerosis.html Cataplerosis and anaplerosis]
* [http://pepck-and-the-ketogenic-diet.com/Triheptanoin-odd-carbon-fats.html triheptanoin oil and odd-carbon fatty acids]