- John Carew Eccles
name = Sir John Eccles
image_width = 150px
caption = John Eccles, shown here at his lab bench
birth_date = birth date|1903|1|27|mf=y
death_date = death date and age|1997|5|2|1903|1|27
nationality = Australian
field = Neuroscience
Nobel Prize in Physiology or Medicine(1963)
Sir John Carew Eccles, AC FRS FRACP FRSNZ FAAS (
January 27, 1903– May 2, 1997) was an Australian neurophysiologistwho won the 1963 Nobel Prize in Physiology or Medicinefor his work on the synapse. He shared the prize together with Andrew Fielding Huxleyand Alan Lloyd Hodgkin.
Eccles was born in
Melbourne, Australia. He attended Melbourne High School and graduated from Melbourne Universityin 1925. He was awarded a Rhodes Scholarshipto study under Charles Scott Sherringtonat Oxford University, where he received his Doctor of Philosophyin 1929.
In 1937 Eccles returned to Australia, where he worked on military research during
World War II. After the war, he became a professor at the University of Otagoin New Zealand. From 1952 to 1962 he worked as a professor at the Australian National University. He won the Australian of the Year Awardin 1963, the same year he won the Nobel Prize.
In 1966 he moved to the
United Statesto work at the Institute for Biomedical Researchin Chicago. Unhappy with the working conditions there, he left to become a professor at the University at Buffalo from 1968 until he retired in 1975. After retirement, he moved to Switzerlandand wrote on the mind-body problem. He died in 1997 in Locarno, Switzerland.
Eccles was a devout
theistand a sometime Roman Catholic, and is regarded by many Christians as an exemplar of the successful melding of a life of science with one of faith. A [http://muse.jhu.edu/journals/perspectives_in_biology_and_medicine/v044/44.2karczmar.pdf biography] states that, "although not always a practicing Catholic, Eccles was a theist and a spiritual person, and he believed 'that there is a Divine Providence operating over and above the materialistic happenings of biological evolution'..."
In the early 1950s, Eccles and his colleagues performed the research that would win Eccles the Nobel Prize. To study synapses in the peripheral nervous system, Eccles and colleagues used the stretch
reflexas a model. This reflex is easily studied because it consists of only two neurons: a sensory neuron (the muscle spindlefiber) and the motor neuron. The sensory neuron synapses onto the motor neuron in the spinal cord. When Eccles passed a current into the sensory neuron in the quadriceps, the motor neuron innervating the quadriceps produced a small excitatory postsynaptic potential(EPSP). When he passed the same current through the hamstring, the opposing muscle to the quadriceps, he saw an inhibitory postsynaptic potential(IPSP) in the quadriceps motor neuron. Although a single EPSP was not enough to fire an action potentialin the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadriceps. On the other hand, IPSPs could subtract from this sum of EPSPs, preventing the motor neuron from firing.
Apart from these seminal experiments, Eccles was key to a number of important developments in
neuroscience. Until around 1949, Eccles believed that synaptic transmissionwas primarily electrical rather than chemical. Although he was wrong in this hypothesis, his arguments led himself and others to perform some of the experiments which proved chemical synaptic transmission. Bernard Katzand Eccles worked together on some of the experiments which elucidated the role of acetylcholineas a neurotransmitter.
* 1932, "Reflex Activity of the Spinal Cord".
* 1953, "The neurophysiological basic of the mind: The principles of neurophysiology", Oxford: Clarendon.
* 1957, "The Physiology of Nerve Cells".
* 1964, "The Physiology of Synapses".
* 1965, "The brain and the unity of conscious experience", London: Cambridge University Press.
* 1969, "The Inhibitory Pathways of the Central Nervous System".
* 1970, "Facing reality: Philosophical Adventures by a Brain Scientist", Berlin: Springer.
* 1973, "The Understanding of the Brain".
* 1977, "The Self and Its Brain", with
Karl Popper, Berlin: Springer.
* 1979, "The human mystery", Berlin: Springer.
* 1980, "The Human Psyche".
* 1984, "The Wonder of Being Human - Our Brain & Our Mind", with
Daniel N. Robinson, New York, Free Press.
* 1985, "Mind and Brain: The Many-Faceted Problems", (Editor), New York : Paragon House.
* 1989, "Evolution Of The Brain : Creation Of The Self".
* 1994, "
How the Self Controls Its Brain".
* Mr John Eccles (1903-1929)
* Dr John Eccles (1929-1944)
* Prof. John Eccles (1944-1958)
* Sir John Eccles (1958-1997)
* [http://nobelprize.org/medicine/laureates/1963/eccles-bio.html Sir John Eccles Biography] . Nobel Foundation.
* Pratt, D.: [http://www.theosophy-nw.org/theosnw/science/prat-bra.htm "John Eccles on Mind and Brain"] . A theosophical view.
* Sabbatini, R.M.E.: [http://www.cerebromente.org.br/n17/history/neurons5_i.htm Neurons and synapses. The history of its discovery IV. Chemical transmission] . "Brain & Mind", 2004.
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