RGS17

Regulator of G-protein signalling 17, also known as RGS17, is a human gene.cite web | title = Entrez Gene: RGS17 regulator of G-protein signalling 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26575| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.cite web | title = Entrez Gene: RGS17 regulator of G-protein signalling 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26575| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Mao H, Zhao Q, Daigle M, "et al." |title=RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. |journal=J. Biol. Chem. |volume=279 |issue= 25 |pages= 26314–22 |year= 2004 |pmid= 15096504 |doi= 10.1074/jbc.M401800200
*cite journal | author=Larminie C, Murdock P, Walhin JP, "et al." |title=Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system. |journal=Brain Res. Mol. Brain Res. |volume=122 |issue= 1 |pages= 24–34 |year= 2004 |pmid= 14992813 |doi= 10.1016/j.molbrainres.2003.11.014
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Fischer T, De Vries L, Meerloo T, Farquhar MG |title=Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8270–5 |year= 2003 |pmid= 12826607 |doi= 10.1073/pnas.1432965100
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sierra DA, Gilbert DJ, Householder D, "et al." |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177–85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693
*cite journal | author=Jordan JD, Carey KD, Stork PJ, Iyengar R |title=Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein. |journal=J. Biol. Chem. |volume=274 |issue= 31 |pages= 21507–10 |year= 1999 |pmid= 10419452 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes